Adjusting cardiopulmonary bypass flow or arterial pressure to maintain renal medullary oxygen

Cardiopulmonary bypass leads to renal hypoperfusion, resulting in medullary hypoxia and acute kidney injury. In instrumented sheep subjected to cardiopulmonary bypass, Lankadeva et  al. found that medullary perfusion and tissue oxygen tension (PO2) was maintained at low-dose metaraminol, an α1-adrenoceptor agonist, because low-dose metaraminol increased perfusion pressure without affecting renal vascular resistance. Lankadeva et al. developed a fiber-optic catheter to measu re bladder urine PO2. Urine PO2 tracks medullary PO2, and low urine PO2 predicts acute kidney injury.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research

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Conclusion: Prior exposure to placental ischemia causes increased salt sensitivity of blood pressure at postpartum probably due to enhanced vasopressin production and secretion.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Experimental hypertension Source Type: research
Conclusions. In this study, we have shown that NMP liver grafts return better coagulation profiles intraoperatively, which could be attributed to the preservation of liver grafts under physiological conditions.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Conclusions. Biliary bicarbonate, pH, and glucose during ex situ NMP of liver grafts are accurate biomarkers of BDI and can be easily determined point of care, making them suitable for the pretransplant assessment of bile duct viability. This may improve graft selection and decrease the risk of posttransplant cholangiopathy.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
We welcome the opportunity to comment on this letter on our editorial.1 We also wish to acknowledge the efforts made by Dr Lazzeri and her colleagues in introducing successful controlled and uncontrolled donation after circulatory death (cDCD and uDCD) programs, despite the local challenges highlighted by the author. We agree that interventions to minimise the damage caused by the inevitable warm ischaemic time and subsequent reperfusion injury are essential in this form of deceased donation, and that in-situ or ex-situ perfusion techniques are showing promise in improving organ utilisation and transplant outcomes of organ...
Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Letter to the Editor Source Type: research
Publication date: Available online 24 June 2019Source: Journal of Cardiology CasesAuthor(s): Hiroki Okabe, Shinjo Sonoda, Koji Abe, Hideki Doi, Toshiyuki Matsumura, Yutaka OtsujiAbstractA 59-year-old female was brought to our emergency room with severe chest pain. Based on the electrocardiogram (ECG) and echocardiography, an acute coronary syndrome (ACS) was suspected. Her initial ECG showed ST elevation in the inferior leads (II, III, and aVF), which had progressed to involve the anterior leads (V2-V4) by the time she was shifted to the catheterization room. A coronary angiogram revealed total occlusion of the mid-left an...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
In this study, we finalize extensive experiments to appraise the image restoration performance at different levels of tube current and spatial and temporal resolution scales. The results demonstrate the capability of our STIR-Net to restore high-quality scans at as low as 11% of absorbed radiation dose of the current imaging protocol, yielding an average of 10% improvement for perfusion maps compared to the patch-based log likelihood method.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
A blunted heart rate (HR) response during dipyridamole myocardial perfusion imaging has been associated with a poor outcome. To assess the value of HR response in patients undergoing high dose dipyridamole stress echocardiography (SE), we retrospectively selected a sample of 3,059 patients (none with pacemakers or atrial fibrillation; mean age 66 ±11 years). All underwent high dose (0.84 mg/kg) dipyridamole SE for evaluation of known or suspected coronary artery disease and/or heart failure in 2 laboratories of Pisa-IFC and Lucca.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
AbstractMost common complications of esophagectomy stem from a perfusion deficiency of the gastric conduit at the anastomosis. Fluorescent tracer imaging allows intraoperative visualization of tissue perfusion. Quantitative assessment of fluorescence dynamics has the potential to identify perfusion deficiency. We developed a perfusion model to analyze the relation between fluorescence dynamics and perfusion deficiency. The model divides the gastric conduit into two well-perfused and two anastomosed sites. Hemodynamics and tracer transport were modeled. We analyzed the value of relative time-to-threshold (RTT) as a predicto...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
AbstractThe use of near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) has gained popularity in many fields in adult surgery, such as sentinel lymph node mapping, intra-operative solid tumor identification, and organ perfusion assessment. However, the clinical application of ICG in pediatric surgery is just at the beginning. This review paper presents the advantages, current applications and potential developments of NIR fluorescence imaging with ICG in our field.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
orreguero D Abstract Our working hypothesis is that a hypoadenosinergic state is a main pathogenetic factor that determines the sensory-motor symptoms and hyperarousal of restless legs syndrome (RLS). We have recently demonstrated that brain iron deficiency (BID) in rodents, a well-accepted animal model of RLS, is associated with a generalized downregulation of adenosine A1 receptors (A1R) in the brain and with hypersensitivity of corticostriatal glutamatergic terminals. Here, we first review the experimental evidence for a pivotal role of adenosine and A1R in the control of striatal glutamatergic transmission and...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
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