Adjusting cardiopulmonary bypass flow or arterial pressure to maintain renal medullary oxygen

Cardiopulmonary bypass leads to renal hypoperfusion, resulting in medullary hypoxia and acute kidney injury. In instrumented sheep subjected to cardiopulmonary bypass, Lankadeva et  al. found that medullary perfusion and tissue oxygen tension (PO2) was maintained at low-dose metaraminol, an α1-adrenoceptor agonist, because low-dose metaraminol increased perfusion pressure without affecting renal vascular resistance. Lankadeva et al. developed a fiber-optic catheter to measu re bladder urine PO2. Urine PO2 tracks medullary PO2, and low urine PO2 predicts acute kidney injury.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research