Posttranslational modifications of sickle hemoglobin in microparticles may promote  injury

Sickle cell disease (SCD) results from a unique mutation in the β-globin gene and is the most common genetic hemoglobinopathy. It is characterized by hemolytic anemia, painful vaso-occlusive crisis, and progressive organ failure, including nephropathy. Red blood cells (RBCs) in patients with SCD are subjected to constant endogenous and exogenous oxidative stres s, which in turn increase hemolysis and contribute to vasculopathies. A gradient of hemolysis among SCD patients influences the SCD phenotype.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research