Under the skin: listening to the voices of older people in influenza immunisation

This report finds that attitudes of older adults to influenza immunisation are a significant factor in influencing the vaccination rates amongst this group. It argues that efforts to increase the vaccination coverage rates among the older population needs to move beyond associating age with vulnerability and towards presenting immunisation as a positive and healthy lifestyle choice.Report
Source: Health Management Specialist Library - Category: UK Health Authors: Tags: Local authorities, public health and health inequalities Source Type: blogs

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Comparative studies of mucosal humoral and cellular immune responses to 2009 pandemic H1N1 influenza virus in mice. Acta Virol. 2019;63(2):203-210 Authors: Zhang YY, An J, Wang K, Han B, Liu YF, Jia HL, Li YS, Lei L, Jia N, Lv J Abstract The nasal-associated lymphoid tissues (NALTs), embedded in the submucosa of murine upper respiratory tract, represents an important site of induction for local mucosal immune responses to airborne pathogens and intranasal vaccines. Here, we systematically investigated the mucosal humoral and cellular immune responses of NALTs in mice infected with A/Beijing/501/2...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
Publication date: Available online 24 June 2019Source: Medicina Intensiva (English Edition)Author(s): M. López-Gobernado, D. Villalba Gil, A. Pérez-Rubio, J.M. Eiros
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
ConclusionsOn average, reimbursements for administering vaccines to privately insured adults were adequate for most private practices. However, providers’ financial concerns may vary across geographic locations.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Despite the availability of yearly vaccinations, influenza continues to cause seasonal and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations that lack immunity to newly emergent strains. The development of a “universal” vaccine is a high priority and many strategies have been proposed, but our current understanding of influenza immunity is incomplete making the development of better influenza vaccines challenging. Influenza immunity has ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Background: Vaccination is a cheap and effective intervention that may prevent infection, which is a recognized trigger for cardiovascular events, and contributes to all-cause mortality. The annual influenza, and five-yearly pneumococcal and herpes zoster vaccinations, are provided free of cost to high-risk patients i.e. those with chronic conditions, indigenous people and those aged over 65. Western Sydney has a high prevalence of at-risk patients.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 146 Source Type: research
Increasing evidence suggests that influenza vaccination can reduce coronary heart disease (CHD) outcomes. CHD and influenza cause a significant burden among Australian adults aged 50 –64, however, vaccine coverage remains suboptimal. The National Immunisation Program (NIP) funds vaccinations in this group only for those at high risk. The aim of this study was to determine whether expanding the NIP to all adults aged 50–64 to prevent acute myocardial infarction (AMI) and resp iratory hospitalisations will be cost beneficial.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 561 Source Type: research
This study is nested within a randomised controlled trial investigating LAIV–microbiome interactions (NCT02972957).FindingsBetween Feb 8, 2017, and April 12, 2017, 118 children were enrolled and received one dose of the Cal09 LAIV from 2016–17. Between Jan 15, 2018, and March 28, 2018, a separate cohort of 135 children were enrolled and received one dose of the NY15 LAIV from 2017–18, of whom 126 children completed the study. Cal09 showed impaired pH1N1 nasopharyngeal shedding (16 of 118 children [14%, 95% CI 8·0–21·1] with shedding at day 2 after administration of LAIV) compared with ...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 21 June 2019Source: The Lancet Respiratory MedicineAuthor(s): Cheryl Cohen, Sheena G Sullivan
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for prophylaxis, and to develop antiviral small-molecules to treat infected patients with convenient, orally administrable drugs. However, developing a vaccine against RSV poses special challenges with the diminished immune system of infants and the elderly, and finding a universal flu vaccine is difficult because the product must target a large array of viral strains. On the other h...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Influenza activity* in the United States during the 2018-19 season (September 30, 2018-May 18, 2019) was of moderate severity (1). Nationally, influenza-like illness (ILI)† activity began increasing in November, peaked during mid-February, and returned to below baseline in mid-April; the season lasted 21 weeks,§ making it the longest season in 10 years. Illness attributed to influenza A viruses predominated, with very little influenza B activity. Two waves of influenza A were notable during this extended season: influenza A(H1N1)pdm09 viruses from October 2018 to mid-February 2019 and influenz...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
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