Validation of ClarityDX Prostate as a Reflex Test to Refine the Prediction of Clinically-significant Prostate Cancer

Condition:   Prostate Cancer Intervention:   Diagnostic Test: Blood test: ClarityDX Prostate Sponsors:   Nanostics;   Alberta Prostate Cancer Research Initiative, APCaRI;   DynaLIFE Medical Laboratories;   Prostate Cencer Centre, Calgary;   Northern Alberta Urology Centre;   Alberta Cancer Foundation;   Alberta Innovates Health Solutions;   Motorcycle Ride for Dad;   Univers ity Hospital Foundation - The Kaye Fund Competition Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Condition:   Prostate Cancer Intervention:   Diagnostic Test: Blood test: ClarityDX Prostate Sponsors:   Nanostics;   Alberta Prostate Cancer Research Initiative, APCaRI;   DynaLIFE Medical Laboratories;   Prostate Cencer Centre, Calgary;   Northern Alberta Urology Centre;   Alberta Cancer Foundation;   Alberta Innovates Health Solutions;   Motorcycle Ride for Dad;   Univers ity Hospital Foundation - The Kaye Fund Competition Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsWe successfully established the protocol for safe intraoperative cavernous nerve monitoring and mapping using CC-EMG during RARP. Its grades were well correlated with erectile function.Patient summaryIn this first-in-human feasibility study, we successfully established the protocol for safe intraoperative cavernous nerve monitoring and mapping method during robot-assisted radical prostatectomy. The results were significantly associated with erectile function. Evaluation of clinical efficacy to preserve potency seems worthy of further optimization and investigation in confirmatory clinical trials.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroinfla...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 13 February 2019Source: Journal of Clinical NeuroscienceAuthor(s): Fairleigh A. Reeves, Shane Battye, Hedley Roth, Justin S. Peters, Christopher Hovens, Anthony J. Costello, Niall M. CorcoranAbstractObjectiveTo describe nerve subtypes involved by perineural invasion (PNI) in prostate cancer and their relationship with clinicopathological parameters and recurrence risk.Methods141 prostatectomy specimens from men with localized prostate cancer and known perineural invasion were analyzed. Index tumor blocks were stained for perineural invasion and sympathetic/parasympathetic markers. For 98 ...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
The study aims to investigate the presence of physiologic prostate-specific membrane antigen (68Ga-PSMA)-ligand uptake on PET in cervical, celiac, and sacral ganglia of the sympathetic trunk as a pitfall for lymph node metastases in prostate cancer imaging. Methods: Four hundred seven patients who underwent Glu-NH-CO-NH-Lys radiolabeled with 68Ga-gallium N,N-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N-diacetic acid (68Ga-PSMA-HBED-CC) PET (combined with a diagnostic CT) were retrospectively analyzed. The number of 68Ga-PSMA PET–positive cervical, celiac, and sacral ganglia was determined, and the configu...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
ConclusionsA major problem with PSA screening—too many unnecessary biopsies—can be mitigated if S3M is used as a reflex test.Patient summaryTo find aggressive prostate cancer with the minimum number of negative biopsies and detection of clinically insignificant cancers, we evaluated the use of a personalized diagnostic prediction model as a second test for men with a positive prostate-specific antigen (PSA) test. We found that this two-step approach could reduce prostate biopsies by a third compared to using PSA alone.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: July 2018Source: European Urology, Volume 74, Issue 1Author(s): Martin Eklund, Peter Ström, Tobias Nordström, Henrik Grönberg
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: July 2018Source: European Urology, Volume 74, Issue 1Author(s): Ola Bratt, Anna Öfverholm
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: July 2018Source: European Urology, Volume 74, Issue 1Author(s): Martin Eklund, Peter Ström, Tobias Nordström, Henrik Grönberg
Source: European Urology - Category: Urology & Nephrology Source Type: research
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