Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan
Condition: Pulmonary Disease, Chronic Obstructive Interventions: Other: Modified American Thoracic Society and National Heart and Lung Institute-Division of Lung Disease Respiratory (Mod. ATS-DLD-078); Other: Modified Medical Research Council (mMRC) Dyspnea Scale; Other: Exacerbations of Chronic Pulmonary Disease Tool (EXACT); Other: COPD Assessmen t Test (CAT); Other: Evaluating Respiratory Symptoms in COPD (E-RS: COPD); Other: Telephonic interviews; Other: Electronic Diary (eDiary); Diagnostic Test: Chest X-ray; Diagnostic Test: Spirometry; Other: Sputum Sampling; Other: Blood sampling Sponsor: GlaxoSmithKline Not yet recruiting
This study will add knowledge about the exercise response in advanced COPD with CRF and verify if an alternative tool, namely HFOT, can increase the benefit obtained from PR.Trial registrationClinicalTrials.gov IDNET03322787Registered: 6 November 2017
AbstractConventional spirometry produces measurement error by using repeatability criteria (RC) to discard acceptable data and terminating tests early when RC are met. These practices also implicitly assume that there is no variation across maneuvers within each test. This has implications for air pollution regulations that rely on pulmonary function tests to determine adverse effects or set standards. We perform a Monte Carlo simulation of 20,902 tests of forced expiratory volume in 1 second (FEV1), each with eight maneuvers, for an individual with empirically obtained, plausibly normal pulmonary function. Default coeffic...
The Evaluating Respiratory Symptoms in Chronic Obstructive Pulmonary Disease (E-RS:COPD) is a patient-reported diary that assesses respiratory symptoms in stable COPD.
The objective of this review is to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, gender, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma - COPD overlap (ACO). PMID: 31154041 [PubMed - as supplied by publisher]
ConclusionsCOPD patients mainly exhibit impaired executive function but not long ‐term memory in cognitive function assessment. Aberrant ALFF alteration in the deep brain may be directly related to lower PaO2 in COPD patients.
The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry,...
Condition: Pulmonary Disease, Chronic Obstructive Interventions: Device: HHHFA Device; Diagnostic Test: Spirometry; Diagnostic Test: 6-minute walk; Diagnostic Test: CT scan; Other: Medical Research Council dyspnea scale (MRC); Other: St. George's Respiratory Questionnaire (SGRQ); Other: COPD Assessment Test (CAT); Other: Pi ttsburgh Sleep Quality Index (PSQI) Sponsors: Spyridon Fortis; American Thoracic Society Not yet recruiting