Engineering Biomaterials to Control the Neural Differentiation of Stem Cells.

Engineering Biomaterials to Control the Neural Differentiation of Stem Cells. Brain Res Bull. 2019 May 16;: Authors: Zimmermann JA, Schaffer DV Abstract Stem cells with the potential for neural differentiation are a promising therapeutic avenue both for treating neurological disease and as a system to advance our fundamental understanding of disease biology in vitro. Precisely controlled extracellular environments that recapitulate critical aspects of embryonic development or the adult stem cell niche are necessary to ensure effective differentiation into the desired cell type. Biomaterials in particular have enabled new avenues for directing stem cell differentiation through the precise presentation of biochemical and biophysical cues. Furthermore, as translation of stem cell technologies necessitates the need for scalable cultures, biomaterials will continue to be valuable tools for guiding stem cell behavior in scalable, complex, three-dimensional cultures. In this review, we highlight the critical signals that guide neurogenesis and how biomaterials can be used to control and direct the neural differentiation of pluripotent and adult stem cells. In addition, we discuss recent new technologies that are further advancing material-based regulation of stem cells. Finally, we highlight the current state of the field and how next-generation biomaterials can enable scalable stem cell culture for cell replacement therapies as well as emerging advanced tissue...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research

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ConclusionsStress conditions induced by locoregional therapies stimulated hCSC enrichment and proliferation, which could be suppressed by niclosamide and inhibitors of pathways important for hCSC renewal. Future studies will determine whether combining locoregional therapies with adjuvant hCSC inhibitors reduces HCC recurrence.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 15 June 2019Source: Journal of Pharmacological SciencesAuthor(s): Takanobu Nakazawa, Ryota Hashimoto, Kazuhiro Takuma, Hitoshi HashimotoAbstractSince induced pluripotent stem cells (iPSCs) were generated from mice and humans by Professor Shinya Yamanaka et al. in 2006 and 2007, respectively, a variety of human-derived cells have been generated, including myocardial, liver, retinal pigment epithelial, and neuronal cells. These iPSCs are now used not only in clinical research focusing on regeneration and transplantation in diverse medical fields, but also in molecular and cellular pathologi...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
In conclusion, our study confers a powerful signal: miR-98-HMGA-POSTN in LSCC, which is able to reverse EMT and inhibit metastasis, underlining the therapeutic potential of this signal.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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Source: Molecular Neurobiology - Category: Neurology Source Type: research
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Source: Annals of Hematology - Category: Hematology Source Type: research
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Source: Stem Cell Research - Category: Stem Cells Source Type: research
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Source: Stem Cell Research - Category: Stem Cells Source Type: research
This study shows the possibility of simultaneous culturing of human OB and OC precursors and demonstrates the efficacy of dopants in the pace change of bone remodeling for bone tissue engineering applications.Graphical abstract
Source: Materials Today Communications - Category: Materials Science Source Type: research
In this study, we engineered different gelatin-based cryogels and studied the effect of nanohydroxyapatite (nHAP) and crosslinking agents on scaffold properties and its osteogenic response towards bone marrow stem cells (BMSCs). The cryogels examined are 5% gelatin and 5% gelatin/2.5% nHAP, crosslinked either with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) or glutaraldehyde (GA). We confirmed that nHAP or the crosslinking agent has no effects on scaffold pore size and porosity. Nonetheless, incorporation of nHAP increased mechanical strength, swelling ratio and degree of crosslinking, but decreased degradation ra...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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