Dynamics of Insulin Signaling in the Black-Legged Tick, Ixodes scapularis

Insulin-like peptides (ILPs) have been identified in several invertebrates, particularly insects, and work on these ILPs has revealed many roles including regulators of energy homeostasis, growth, development and lifespan to name a few. However, information on arthropod ILPs outside of insects is sparse. Studies of Ixodid tick ILPs are particularly scarce, despite their importance as vectors of infectious agents, most notably Lyme disease. The recent publication of the genome of the black-legged tick, Ixodes scapularis, has advanced opportunities to study this organism from a molecular standpoint, a resource sorely needed for an organism with challenging life history requirements for study in the laboratory, such as a long life cycle and obligate, prolonged, blood-feeding at each life stage. Through bioinformatics searches of the tick genome and other available I. scapularis databases, we identified 4 four putative ILP sequences. Full-length sequences of these ILP transcripts were confirmed, and quantitative RT-PCR was used to examine expression levels of these ILPs in different life stages and adult tissues. This work serves as an initial characterization of ILP expression in ticks and provides the foundation for further exploration of the roles of ILPs in these important arthropod vectors.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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Publication date: Available online 16 October 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Nicole E. Breuner, Shelby L. Ford, Andrias Hojgaard, Lynn M. Osikowicz, Christina M. Parise, Maria F. Rosales Rizzo, Ying Bai, Michael L. Levin, Rebecca J. Eisen, Lars EisenAbstractThe invasive, human-biting Asian longhorned tick, Haemaphysalis longicornis, was detected in New Jersey in the eastern United States in August of 2017 and by November of 2018 this tick had been recorded from 45 counties across 9 states, primarily along the Eastern Seaboard. The establishment of H. longicornis in the United States has raised the ques...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
LYME disease is a bacterial infection spread to humans by infected ticks. Ticks are tiny spider-like creatures found in woodland and heath areas. They feed on the blood of birds, mammals and humans. Feeling this sensation in your head could mean you have Lyme disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Rapid assay for Lyme disease could lead to a practical test for use by healthcare providers.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Updated Date: Tue, 15 Oct 2019 00:00:00 EDT
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DR MARTIN SCURR: Pat Toovey from Norfolk found a tick on his wife's back two years ago and she is constantly in pain and struggles to get out of bed. He fears she has Lyme disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSION: Different specific molecules of the vector, pathogen and host result in LNB establishment. After B. burgdorferi species penetrate host skin through a tick bite, they are confronted by the immune defenses of the host. However, they are helped by specific proteins in different interactions, and the disease is established. The interactions between the vector, pathogen and host are shown in Table 1 and Figure 1. Knowledge of these molecular interactions can aid development of therapeutics against LNB and LD. Others: We systematically describe the different molecular tick-pathogen-host interactions. PMID: 31613...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research
H, Heylen D Abstract Wild birds are frequently exposed to the zoonotic tick-borne bacteria Borrelia burgdorferi sensu lato (s.l.), and some bird species act as reservoirs for some Borrelia genospecies. Studying the tropism of Borrelia in the host, how it is sequestered in different organs, and whether it is maintained in circulation and/or in the host's skin is important to understand pathogenicity, infectivity to vector ticks and reservoir competency.We evaluated tissue dissemination of Borrelia in blackbirds (Turdus merula) and great tits (Parus major), naturally and experimentally infected with Borrelia genospe...
Source: Microbial Ecology - Category: Microbiology Authors: Tags: Microb Ecol Source Type: research
Researchers at Columbia University have developed a microfluidic device that can diagnose Lyme disease in as little as 15 minutes. The device is particularly accurate in identifying antibody biomarkers that are present during early stage Lyme disease...
Source: Medgadget - Category: Medical Devices Authors: Tags: Diagnostics Medicine Neurology Pathology Public Health Source Type: blogs
Discussion Lyme disease (LD) is caused by several genospecies of Borrelia burgdorferi senu lato that are transmitted by ticks of the Ixodes ricinus complex. In the U.S. and Europe it is the most common vector-borne disease. It is named for Lyme, Connecticut in the 1970s when it was “discovered,” but there are reports of LD-type disease in Europe since 1883. There are 18 distinct genospecies with B. afzelii, B. garinii and B. burgdorferi sensu stricto being the 3 most common ones causing human infection. There are many species of Ixodes ticks but only 4 commonly bite humans. Ixodes ricinus mainly in Europe, I, p...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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