Autophagy dysfunction in Alzheimer ’s disease: mechanistic insights and new therapeutic opportunities
Alzheimer ’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss due to aberrant accumulation of misfolded proteins inside and outside neurons and glial cells leading to a loss of cellular protein homeostasis. Today, no therapy is available to block or slow down AD progress ion and the mechanisms of the disease are not fully understood. Autophagy is an intracellular degradation pathway crucial to maintaining cellular homeostasis by clearing damaged organelles, pathogens, and unwanted protein aggregates.
Source: Biological Psychiatry - Category: Psychiatry Authors: Antonio Di Meco, Mary Elizabeth Curtis, Elisabetta Lauretti, Domenico Pratic ό Tags: Review Source Type: research