Exploitation of glycosylation in enveloped virus pathobiology

Publication date: Available online 20 May 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yasunori Watanabe, Thomas A. Bowden, Ian A. Wilson, Max CrispinAbstractGlycosylation is a ubiquitous post-translational modification responsible for a multitude of crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to glycosylate their own proteins during replication. Viral envelope proteins from a variety of human pathogens including HIV-1, influenza virus, Lassa virus, SARS, Zika virus, dengue virus, and Ebola virus have evolved to be extensively glycosylated. These host-cell derived glycans facilitate diverse structural and functional roles during the viral life-cycle, ranging from immune evasion by glycan shielding to enhancement of immune cell infection. In this review, we highlight the imperative and auxiliary roles glycans play, and how specific oligosaccharide structures facilitate these functions during viral pathogenesis. We discuss the growing efforts to exploit viral glycobiology in the development of anti-viral vaccines and therapies.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research

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Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research
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Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
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Source: Journal of Theoretical Biology - Category: Biology Source Type: research
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Source: Biologicals - Category: Biology Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Authors: Vicentini CB, Manfredini S, Maritati M, Di Nuzzo M, Contini C Abstract Gonorrhea can be traced back to the earliest records of the human race even if Albert Neisser first described gonococcus in 1879. The Romans, Jews and Arabs all have documents referring to gonorrhea and each society had their own description of symptoms and treatment. The Roman physician Galen in 130 AD described the disease as an "involuntary escape of semen". The word itself derives from the Greek, meaning "the flow of seed". Gonorrhea is currently the second most commonly notifiable sexually transmitted infection ...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
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Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
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Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
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Source: Epidemics - Category: Epidemiology Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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