Black phosphorus –polypyrrole nanocomposites for high-performance photothermal cancer therapy

New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ01249D, PaperChengkang Su, Huiqing Zhong, Haolin Chen, Yanxian Guo, Zhouyi Guo, Deqiu Huang, Wen Zhang, Qiang Wu, Biwen Yang, Zhiming Liu Black phosphorus –polypyrrole nanosheets with superimposed NIR absorption have been fabricated as the novel nanotherapeutic agent for enhanced NIR photothermal cancer therapyin vitro andin vivo. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research

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Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): Marina V. Novoselova, Denis V. Voronin, Tatiana O. Abakumova, Polina A. Demina, Arsenii V. Petrov, Vladimir V. Petrov, Timofei S. Zatsepin, Gleb B. Sukhorukov, Dmitry A. GorinAbstractHigh intensity focused ultrasound (HIFU) is widely used in medical practice, including cancer therapy. Also this approach is promising for remote release of encapsulated drugs in various other biomedical applications where local treatment is needed. Our approach underpins the minimization of HIFU impact on possible degradation of biological t...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Conclusion Considering the domains of HRQoL of the women treated for cervical cancer, a better score was observed in the domains of physical and social/family wellbeing. For most domains, better scores were found between those with a current occupation, with a longer time after the diagnosis and treatment, and among those who had undergone a hysterectomy.Resumo Objetivo Analisar os fatores associados à qualidade de vida em mulheres com câncer de colo do útero tratadas em um hospital de referência no Rio de Janeiro, RJ, Brasil. Métodos Estudo transversal em mulheres com diagnóstico de...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Publication date: September 2019Source: Biomedicine &Pharmacotherapy, Volume 117Author(s): Chao-Yue Sun, Juan Nie, Jie-Peng Huang, Guang-Juan Zheng, Bing FengAbstractCisplatin is one of the most frequently used chemotherapeutic agents for treatment of a wide range of cancer types. Nevertheless, the intrinsic or acquired resistance to cisplatin remains a major obstacle for cancer therapy. There are a number of factors contributing to the onset of this phenotype resistance. Signal transducers and activators of transcription 3 (STAT3) is constitutively activated in many cancer types, and such hyperactivation is associated...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Kroker L, Dubois C, Münstedt K, Büntzel J, Keinki C, Hübner J Abstract This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever, headache, limb pain and sleep disorders had a significant influence on the patients' satisfaction with life (p = .034 and p = .032, respectively). Concerning CAM, we could not detect any association between...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Contributors : Jian Liu ; Francesco J DeMayoSeries Type : Expression profiling by arrayOrganism : Mus musculusERBB2 is an oncogenic driver with frequent gene mutations and amplification in human lung tumors and is an attractive target for lung cancer therapy. However, target therapies can be improved by understanding the in vivo mechanisms regulated by ERBB2 during lung tumor development. Here, we generated genetic mouse models to show that Erbb2 loss inhibited lung tumor development induced by deletion of Pten and Smad4. Transcriptome analysis showed that Erbb2 loss suppressed the significant changes of most of the induce...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
eau One of the main characteristics of carcinogenesis relies on genetic alterations in DNA and epigenetic changes in histone and non-histone proteins. At the chromatin level, gene expression is tightly controlled by DNA methyl transferases, histone acetyltransferases (HATs), histone deacetylases (HDACs), and acetyl-binding proteins. In particular, the expression level and function of several tumor suppressor genes, or oncogenes such as c-Myc, p53 or TRAIL, have been found to be regulated by acetylation. For example, HATs are a group of enzymes, which are responsible for the acetylation of histone proteins, resulting in...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionCollectively, these results reveal that MSCs can help colorectal cancer cells defend against senescence through P53/P21 pathway, which may be a new strategy for colorectal cancer therapy.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
We have recently discovered that cancer cells take up extracellular citrate through a plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract Humans are a colonized with trillions of commensal microorganisms which exert a profound effect on normal host physiology and immune function through an abundance of genetic and metabolic by-products. Although the commensal microbiome has beneficial functions to host physiology, perturbations of the composition of the commensal microbiome or the homeostatic mucosal environment can lead to the induction of immune pathology and systemic inflammation. In the context of cancer progression or response to immune therapy, this inflammation can be detrimental, resulting in tumor growth and the promotion of immune...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b07979
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
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