IJERPH, Vol. 16, Pages 1779: Single Core Genome Sequencing for Detection of both Borrelia burgdorferi Sensu Lato and Relapsing Fever Borrelia Species
This study presented examples of base-calling DNA sequencing electropherograms routinely generated in a clinical diagnostic laboratory on DNA extracts of human blood specimens and ticks collected from human skin bites and from the environment. Since some of the tick samples tested were collected in Ireland, borrelial species or strains not known to exist in the United States were also detected by analysis of this 16S rRNA “core genome”. We recommend that hospital laboratories located in Lyme disease endemic areas begin to use a “core genome” sequencing test to routinely diagnose spirochetemia caused by various species of borreliae for timely management of patients at the early stage of infection.
Most health system executives understand that significant changes are necessary in healthcare to adapt to the preferences of today's consumers while cutting costs and delivering quality care. A recent article quoted an executive of the Cleveland Clinic about three major trends that are shaping the health systems for the future (see:Why Today ’s Hospitals and Health Systems Need to Be More Patient-Centric to Fight Rising Costs). Below is an excerpt from it:“A central challenge for the United States is that between 18 to 20 percent of GDP is going to healthcare, and it’s on track to go higher,&rdqu...
AbstractEach year, many young professionals forego advanced education in the traditional doctoral programs of medicine, law, and philosophy in favor of pursuing a PhD or professional doctorate in bioethics or healthcare ethics that is offered by several major institutes of higher education across the United States. These graduates often leverage their degrees into careers within the broader field of bioethics. As such, they represent a growing percentage of professional bioethicists in both academia and healthcare nationwide. Given the significant role that doctoral bioethics programs play in the training of future profess...
In this study, we identified AIRE as a cytokine-induced RA risk gene in RA FLS and explored its role in these pathogenic stroma cells. Using RNA interference and RNA sequencing we show that AIRE does not induce TRAs in FLS, but augments the pro-inflammatory response induced by tumor necrosis factor and interleukin-1beta by promoting the transcription of a set of genes associated with systemic autoimmune disease and annotated as interferon-gamma regulated genes. In particular, AIRE promoted the production and secretion of a set of chemokines, amongst them CXCL10, which have been associated with disease activity in RA. Final...
This study sought to address limited understanding of the inpatient experience of transgender adolescents. This study uses qualitative methods to gain insight into the experience of transgender adolescents and psychiatric care providers on an adolescent inpatient psychiatric unit in the northeast United States. Semi-structured interviews were conducted with patients (9 total, ages 13 –17) and unit care providers (18 total). These interviews were recorded, transcribed, and analyzed using inductive thematic analysis. Patients and providers generally reported a supportive inpatient environment. Factors that contributed ...
Authors: Gras E, Bailly E, Le Brun C, Lemaignen A, Lanotte P PMID: 31202618 [PubMed - as supplied by publisher]
The measles outbreak in the United States continues to grow, with the number of cases this year now reaching 1,044 as of Friday, according to the US Centers for Disease Control and Prevention.
The United States recorded 22 new measles cases last week, bringing the year's total number of cases to 1,044 in the worst outbreak of the disease since 1992, federal health officials said on Monday.
Tests can help clinicians assess patients with suspected inflammatory arthritis, but'it shouldn't drive'treatment, an expert reminds rheumatologists.Medscape Medical News
The president wants to terminate at least a third of all federal advisory committees by the end of September.
More News: Arthritis | Borrelia | Databases & Libraries | Department of Health | Endemics | Environmental Health | Genetics | Hospitals | International Medicine & Public Health | Ireland Health | Laboratory Medicine | Lyme Disease | Politics | Rheumatology | Skin | Study | Tickborne Diseases | USA Health