Mesothelioma Clinical Trial Exploring Family Predisposition

The National Cancer Institute has opened a clinical trial using mesothelioma patients and their family members to explore predisposition to the cancer and potential solutions to negating it. The trial is a follow up to an earlier study of a genetic mutation that creates susceptibility to various cancers but a longer-than-normal survival with platinum-based chemotherapy treatment. “This is an important, long-term study that could have implications not only for a patient, but for family members, too,” Dr. Raffit Hassan, NCI senior investigator told The Mesothelioma Center at “Progress can be made in terms of prevention and early detection.” Tracking Inherited Mutations In the clinical trial, Hassan and his staff will be studying mutations of BAP1, a tumor-suppressor gene, and other similar-acting genes. Children as young as 2 years old will be eligible to participate. Participants who have a confirmed mutation will be encouraged to ask relatives to join the study. They also will have an option of being in a remote group — providing medical and family history by phone annually — or in a more closely monitored setting that includes blood tests, scans and physical exams. The mutations also have been associated with renal and basal cell carcinoma, cutaneous melanoma and meningioma. Relatives identified with the mutations but no cancer emergence would be encouraged to avoid risk factors such as exposure to asbestos and other toxins....
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

Related Links:

Using 3D-printed models based on chest CT scans allows clinicians to personalize...Read more on AuntMinnie.comRelated Reading: AR, 3D printing enhance planning for complex heart surgery Radiologists rally in support of medical 3D printing AR, 3D printing aid presurgical planning for kidney cancer 3D printing reduces liver transplant costs, surgery time 3D printing boosts efficiency of rib fracture repair
Source: Headlines - Category: Radiology Source Type: news
Publication date: Available online 15 June 2019Source: Journal of Prosthodontic ResearchAuthor(s): Ricardo Schestatsky, Camila Pauleski Zucuni, Kiara Serafini Dapieve, Thiago Augusto Lima Burgo, Aloísio Oro Spazzin, Ataís Bacchi, Luiz Felipe Valandro, Gabriel Kalil Rocha PereiraAbstractPurposeTo characterize the effect of two processing techniques (pressing and CAD/CAM — Computer Aided Design/Computer Aided Machining) of lithium-disilicate (LD) based crowns on the microstructure, topography, roughness, fractal dimension, internal and marginal adaptation.MethodsOne-hundred identical preparations for mono...
Source: Journal of Prosthodontic Research - Category: Dentistry Source Type: research
Conclusions: Due to the complexity of the behavior and biology of cells, scientists' primary focus should be on detection and elimination of sources of inflammation. Antiparasitic medications, and also antiviral, antibiotic, and antifungal medications should be thought of as underrecognized, underappreciated, and forgotten medications that can be part of cancer therapy. The information offered in this review suggests scientists should think of cancer not only as a metabolic disease but also as a metabolic parasite and should consider using antiparasitic medications under a new understanding of the role of inflammation, inf...
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
Conclusions: While case reports cannot be considered as proof of efficacy, these cases added to others of patients treated with the same method would suggest that this is a viable option for those patients whose disease cannot be treated successfully with other modalities. PMID: 31202206 [PubMed - in process]
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 15 June 2019Source: Seminars in Cancer BiologyAuthor(s): Michael Timaner, Kelvin Tsai, Yuval ShakedAbstractMesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epit...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Ryan Wendt, Yubo Gao, Benjamin J. MillerAbstractBackgroundThere is an undefined relationship between access to regional referral centers and whether the eventual oncologic outcomes are influenced by distance, travel time, or residence in a rural community.MethodsWe used the Surveillance, Epidemiology and End Results (SEER) Program Database to capture all cases of high-grade osteosarcoma from 1990 to 2014 in Iowa, Utah, and New Mexico. Using univariate, Kaplan Meier survival analysis, and multivariate Cox proportional hazards modeling we analyzed ...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionsCNS-RF is a relevant measure of prognosis in patients who have already achieved a period of remission. Providing an updated estimation of prognosis in the years following diagnosis may improve the survivors’ quality of life and access to credit or insurance.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
On Nov. 17, 1973, investigators reported that a portion of conversation of one tape recorded in the Oval Office had been erased. ... You are leaving and going to the website of our trusted...
Source: News - Category: American Health Source Type: news
More News: Academies | Asbestosis | Basal Cell Carcinoma | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Chemotherapy | Children | Clinical Trials | Environmental Health | Gastroschisis Repair | Genetics | Immunotherapy | Melanoma | Men | Mesothelioma | Ovarian Cancer | Ovaries | PET Scan | Skin Cancer | Study