Mesothelioma Clinical Trial Exploring Family Predisposition

The National Cancer Institute has opened a clinical trial using mesothelioma patients and their family members to explore predisposition to the cancer and potential solutions to negating it. The trial is a follow up to an earlier study of a genetic mutation that creates susceptibility to various cancers but a longer-than-normal survival with platinum-based chemotherapy treatment. “This is an important, long-term study that could have implications not only for a patient, but for family members, too,” Dr. Raffit Hassan, NCI senior investigator told The Mesothelioma Center at Asbestos.com. “Progress can be made in terms of prevention and early detection.” Tracking Inherited Mutations In the clinical trial, Hassan and his staff will be studying mutations of BAP1, a tumor-suppressor gene, and other similar-acting genes. Children as young as 2 years old will be eligible to participate. Participants who have a confirmed mutation will be encouraged to ask relatives to join the study. They also will have an option of being in a remote group — providing medical and family history by phone annually — or in a more closely monitored setting that includes blood tests, scans and physical exams. The mutations also have been associated with renal and basal cell carcinoma, cutaneous melanoma and meningioma. Relatives identified with the mutations but no cancer emergence would be encouraged to avoid risk factors such as exposure to asbestos and other toxins....
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 15 June 2019Source: Journal of Prosthodontic ResearchAuthor(s): Ricardo Schestatsky, Camila Pauleski Zucuni, Kiara Serafini Dapieve, Thiago Augusto Lima Burgo, Aloísio Oro Spazzin, Ataís Bacchi, Luiz Felipe Valandro, Gabriel Kalil Rocha PereiraAbstractPurposeTo characterize the effect of two processing techniques (pressing and CAD/CAM — Computer Aided Design/Computer Aided Machining) of lithium-disilicate (LD) based crowns on the microstructure, topography, roughness, fractal dimension, internal and marginal adaptation.MethodsOne-hundred identical preparations for mono...
Source: Journal of Prosthodontic Research - Category: Dentistry Source Type: research
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Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
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Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 15 June 2019Source: Seminars in Cancer BiologyAuthor(s): Michael Timaner, Kelvin Tsai, Yuval ShakedAbstractMesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epit...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
On Nov. 17, 1973, investigators reported that a portion of conversation of one tape recorded in the Oval Office had been erased. ... You are leaving AARP.org and going to the website of our trusted...
Source: AARP.org News - Category: American Health Source Type: news
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