Evaluation of Low-Level Laser Therapy Efficacy in Pain Management of Grade 2 Oral Mucositis Induced by Radiotherapy or Chemoradiotherapy: a Phase II Randomized Study in Patients With Upper Aerodigestive Tract Cancer

Condition:   Upper Aerodigestive Tract Neoplasms Interventions:   Device: Basic Oral Care + active LLLT;   Other: Basic oral Care + inactive LLLT;   Other: Basic Oral Care Sponsor:   Institut Claudius Regaud Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Patient compliance and contentment without any postoperative complications were observed to be of high degree in the present study. Thus diode laser can be considered as a best alternative to conventional surgical treatment modality in managing OL and OLP and preventing its further transformation. PMID: 30583693 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
We report seven cases of oral cGVHD that were treated with photobiomodulation therapy (PBM), previously known as low-level laser therapy (LLLT). Patients underwent at least two PBM treatments per week in addition to local treatment with steroids, and if on systemic therapies, these were either unchanged or dosage was reduced during the period of PBM therapy. Follow-up data is presented for 4  weeks of treatment.ResultsOral pain, sensitivity, and dry mouth improved in most patients. These findings suggest PBM therapy may represent an additional approach for management of oral cGVHD, and suggest that controlled studies ...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: The protocols suggestive for managements of oral mucositis and pain with MuGard - mucoadhesive hydrogel; PerioAid Tratamiento® antiseptic mouthrinse with chlorhexidine and cetylpyridinium chloride; Episil® plus benzydamine - bioadhesive oromucosal gel; 0,03% of Triclosan mouthwash Colgate Plax; and Diode Laser Therapy of low-level are safe for oncology patients applied according to adopted clinical parameters. PMID: 27918734 [PubMed - as supplied by publisher]
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
Oral mucositis (OM) is a very common side effect of head and neck radiation therapy (RT) and concurrent chemotherapy and radiation (CRT) leading to severe pain, infection, weight loss, higher rates of hospitalization, higher financial cost of treatment, and breaks in therapy resulting in increased morbidity and reduced treatment efficacy. The 2014 guidelines from The Mucositis Study Group of the Multinational Association of Supportive Care in Cancer included a suggestion that low-level laser therapy (LLLT) was useful for the prevention of high-grade OM in patients receiving head and neck RT alone, but no comment could be m...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Posters Source Type: research
Low level laser therapy (LLLT) was first introduced for potential clinical applications by Mester in the late 1960s. This form of laser treatment, currently referred to as photobiomodulation (PBM), limits radiation intensity by transferring low energy to tissues and thereby does not generate heat. Among the clinical indications for which LLLT has been reported to be efficacious are pain relief (back and neck, orthodontic, shoulder), wound healing, carpal tunnel syndrome, colorectal cancer, elbow disorders, fibromyalgia, lymphedema, musculoskeletal dysfunction, myofascial pain syndrome, neurological dysfunctions, patella-fe...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Abstract Oral mucositis (OM) and radiodermatitis (RD) are serious side effects of radiotherapy (RT), often leading to its suspension, need for analgesics, and enteral/parenteral nutrition. Laser therapy is becoming a recommended treatment option. This prospective study aimed at demonstrating the beneficial effect of class IV laser therapy (HPLT) on RT-induced OM, an off-label use of HPLT to treat RD in breast cancer patients. Fifty-three cancer patients, during/after RT and/or chemotherapy (CT), affected by OM, were treated with HPLT during four consecutive days (970 ± 15 nm, 5 W (50...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
CONCLUSIONS: The very encouraging results of LLLT in the prevention and treatment of OM in patients treated by chemotherapy or radiotherapy for advanced head and neck cancer could soon be proposed as a new standard of care, according to the multinational Association of Supportive care in Cancer (MASCC) criteria. Modern lasers are less time consuming and extraoral applicators for a possible use by trained paramedical staff could be helpful to complete clinician practice. A preventive dose of 2 J/cm(2) and a curative dose of 4 J/cm(2) if using a red wavelength lasers are now recommended. PMID: 24511199 [PubMed]
Source: Laser Therapy - Category: Laser Surgery Tags: Laser Ther Source Type: research
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