Using Boot Camp Translation to Address Rural Disparities in Adolescent Vaccination

Condition:   Primary Prevention Interventions:   Behavioral: Boot Camp Translation;   Other: Control Sponsors:   University of Colorado, Denver;   Centers for Disease Control and Prevention Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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We examined the role of maternal HIV disease progression, infant factors, placental Fc receptor expression, IgG subclass, and glycan signatures and their association with placental IgG transfer efficiency. Maternal IgG characteristics, such as binding to placentally expressed Fc receptors FcγRIIa and FcγRIIIa, and Fc region glycan profiles were associated with placental IgG transfer efficiency. Our findings suggest that Fc region characteristics modulate the selective placental transfer of IgG, with implications for maternal vaccine design and infant health.Graphical Abstract
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 13 June 2019Source: CellAuthor(s): Daniel G.W. Alanine, Doris Quinkert, Rasika Kumarasingha, Shahid Mehmood, Francesca R. Donnellan, Nana K. Minkah, Bernadeta Dadonaite, Ababacar Diouf, Francis Galaway, Sarah E. Silk, Abhishek Jamwal, Jennifer M. Marshall, Kazutoyo Miura, Lander Foquet, Sean C. Elias, Geneviève M. Labbé, Alexander D. Douglas, Jing Jin, Ruth O. Payne, Joseph J. IllingworthSummaryThe Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 13 June 2019Source: CellAuthor(s): Madeleine F. Jennewein, Ilona Goldfarb, Sepideh Dolatshahi, Cormac Cosgrove, Francesca J. Noelette, Marina Krykbaeva, Jishnu Das, Aniruddh Sarkar, Matthew J. Gorman, Stephanie Fischinger, Carolyn M. Boudreau, Joelle Brown, Jennifer H. Cooperrider, Jasneet Aneja, Todd J. Suscovich, Barney S. Graham, Georg M. Lauer, Tessa Goetghebuer, Arnaud Marchant, Douglas LauffenburgerSummaryDespite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immu...
Source: Cell - Category: Cytology Source Type: research
This study provides a convenient method for the genetic manipulation of V. mimicus. It will facilitate the identification and characterization of V. mimicus virulence factors and eventually contribute to a better understanding of V. mimicus pathogenicity and development of attenuated vaccine.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 13 June 2019Source: EpidemicsAuthor(s): Giorgio GuzzettaAbstractA major outbreak of Hepatitis A Virus (HAV) has swept through Europe between mid-2016 and 2017, mainly within the community of men who have sex with men (MSM). Over the same period, about 1,000 outbreak-related cases of acute Hepatitis A (AHA) were recorded in Lazio region, Italy.We calibrated a Bayesian model to reconstruct likely transmission events within all 44 households where multiple infections were recorded, representing a total of 103 cases from the HAV outbreak in Lazio. Based on information on the observed times of...
Source: Epidemics - Category: Epidemiology Source Type: research
Francisella tularensis is the causative agent of tularemia and has gained recent interest as it poses a significant biothreat risk. F. novicida is commonly used as a laboratory surrogate for tularemia research due to genetic similarity and susceptibility of mice to infection. Currently, there is no FDA-approved tularemia vaccine, and identifying therapeutic targets remains a critical gap in strategies for combating this pathogen. Here, we investigate the soluble lytic transglycosylase or Slt in F. novicida, which belongs to a class of peptidoglycan-modifying enzymes known to be involved in cell division. We assess the role...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: PMID: 31194485 [PubMed - in process]
Source: American Family Physician - Category: Primary Care Tags: Am Fam Physician Source Type: research
ConclusionsIn this review, we summarize antagonistic concurrent infections involving parasites and provide a functional framework for in-depth studies of the underlying mechanisms of coinfection with different microorganisms, which will hasten the development of promising antimicrobial alternatives, such as novel antibacterial vaccines or biological methods of controlling infectious diseases, thus relieving the overwhelming burden of ever-increasing antimicrobial resistance.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Publication date: Available online 14 June 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Alexandros Psarris, Michael Sindos, Georgios Daskalakis, Maria Eleni Chondrogianni, Stefani Panayiotou, Panagiotis Antsaklis, Dimitrios LoutradisAbstractMaternal immunization during pregnancy provide protection for the mother and the fetus against certain pathogens. Immunizations during pregnancy are divided to routine immunizations recommended for all pregnant women, immunizations for certain medical indications and vaccines that are potentially harmful during pregnancy and should be avo...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Even with more than 1,400 dead, the W.H.O. says the risk of the disease spreading beyond the region remains low and declaring an emergency could have backfired.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Epidemics Ebola Virus Vaccination and Immunization World Health Organization Centers for Disease Control and Prevention United Nations Children ' s Fund Congo, Democratic Republic of (Congo-Kinshasa) Africa Uganda Tedros Adhanom Gheb Source Type: news
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