Reneo Pharmaceuticals Raises $50 Million to Develop Therapeutics to Treat Genetic Mitochondrial Diseases

SAN DIEGO, May 20, 2019 -- (Healthcare Sales &Marketing Network) -- Reneo Pharmaceuticals, a clinical stage pharmaceutical company, today announced that it has completed a $50 million Series A financing to develop therapies for diseases associated with d... Biopharmaceuticals, Venture Capital Reneo Pharmaceuticals, mitochondrial diseases
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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Publication date: Available online 23 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Muneeb A. Faiq, Gadi Wollstein, Joel S. Schuman, Kevin C. ChanAbstractThe cholinergic system has a crucial role to play in visual function. Although cholinergic drugs have been a focus of attention as glaucoma medications for reducing eye pressure, little is known about the potential modality for neuronal survival and/or enhancement in visual impairments. Citicoline, a naturally occurring compound and FDA approved dietary supplement, is a nootropic agent that is recently demonstrated to be effective in ameliorating ischemi...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Polyunsaturated fatty acids (PUFAs) including epoxide-modified -3 and -6 fatty acids are made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function as signaling molecules. A critical PUFA, arachidonic acid (ARA), is metabolized to a diverse set of lipids signaling molecules through cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 epoxygenase, or cytochrome P450 hydroxylase, however the majority of ARA is metabolized into anti-inflammatory epoxides via cytochrome P450 enzymes. These short-lived epoxide lipids are rapidly metabolized or inactivated by the soluble epoxide hydrol...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ng Yang Pinocembrin is one of the most abundant flavonoids in propolis, and it may also be widely found in a variety of plants. In addition to natural extraction, pinocembrin can be obtained by biosynthesis. Biosynthesis efficiency can be improved by a metabolic engineering strategy and a two-phase pH fermentation strategy. Pinocembrin poses an interest for its remarkable pharmacological activities, such as neuroprotection, anti-oxidation, and anti-inflammation. Studies have shown that pinocembrin works excellently in treating ischemic stroke. Pinocembrin can reduce nerve damage in the ischemic area and reduce mitochon...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Lewy body dementia (LBD) is a major public health problem worldwide. Prevalence of Lewy body dementia (LBD) is second only to Alzheimer's disease (AD) among people with neurodegenerative dementia.1 LBD cause earlier mortality,2 earlier nursing home admissions, poorer quality-of-life, higher costs,3 more frequent falls, and more caregivers ’ burden than AD. LBD include two overlapping clinical syndromes, dementia with Lewy bodies (DLB) and Parkinson's disease (PD) dementia (PDD). They cause more frequent and more intense neuropsychiatric symptoms including visual hallucinations, delusions, agitation, and depression than AD.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
Mitochondria produce more than 90% of the energy required by our bodies and thereby have a fundamental role in cell and energy metabolism. Mitochondria are composed of proteins encoded by both the nuclear and mitochondrial genomes and the coordinated expression of both genomes is essential for energy production. Impaired energy production leads to mitochondrial dysfunction that causes or contributes significantly to a variety of diseases including metabolic disorders and cardiovascular diseases.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 035 Source Type: research
This study found that EPC metabolic profile is a direct determinant of EPC fate. The Wnt signaling pathway regulates EPC metabolism, EPC fate and subsequently, new vessel formation. These findings reveal a new function of Wnt signaling in regulating mitochondrial function in EPC. This study also suggests a potential significance of EPC metabolic profile as a diagnostic marker and therapeutic target for diseases caused by abnormal blood vessel formation.© AlphaMed Press 2019
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
Cell Death &Disease, Published online: 24 June 2019; doi:10.1038/s41419-019-1734-7Mitochondrial miR-762 regulates apoptosis and myocardial infarction by impairing ND2
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 21 June 2019Source: Neurochemistry InternationalAuthor(s): Amica C. Müller-Nedebock, Rebecca R. Brennan, Marianne Venter, Ilse S. Pienaar, Francois H. van der Westhuizen, Joanna L. Elson, Owen A. Ross, Soraya BardienAbstractParkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are highly dependent on mitochondrial adenosine tri...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
This study provides novel insights into the molecular mechanisms underlying the anti-atherogenic actions of DGLA and supports further assessments on its protective effects on plaque regression in vivo and in human trials.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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