Detection of serum protein and circulating mRNA of cMET, HGF EGF and EGFR levels in lung cancer patients to guide individualized therapy.
CONCLUSION: To our knowledge this is the first study comparing the levels of protein and mRNA in the serum material of HGF, c-MET, EGF and EGFR parameters in lung cancer patients' blood samples. Further prospective studies with more participants for better understanding of mechanism and effect for HGF and c-MET inhibitors in lung cancer will help us to identify of these biomarkers role for guiding us to sellect individualized itargeted therapies. PMID: 31104010 [PubMed - as supplied by publisher]
(Wiley) Survivors of childhood brain tumors who received radiotherapy and were very young at the time of diagnosis may experience cognitive and socioeconomic burdens decades after treatment, according to a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Interventions such as cognitive therapies and educational and occupational services may be needed to mitigate such long-term effects.
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0495-5The role of mouse tumour models in the discovery and development of anticancer drugs
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0500-zObesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0504-8RRx-001 followed by platinum plus etoposide in patients with previously treated small-cell lung cancer
ConclusionOCWAA is uniquely positioned to study the epidemiology of EOC in AA women compared with white women to address disparities. Studies of EOC have been underpowered to address factors that may explain AA-white differences in the incidence and survival. OCWAA promises to provide novel insight into disparities in ovarian cancer.
Conclusions Knowing that the incidence of lung cancer increased globally in both male and female, the relatively lower male to female ratio when compared with other studies, may reflect at least an increasing in the lung cancer rates among female. Smoking still remains the major risk factor in pathogenesis of primary lung cancer. COPD could be considered an important respiratory disorder that tied to bronchogenic carcinoma risk. Interestingly, the incidence of adenocarcinoma surpassed that of squamous cell carcinoma. Unfortunately, presentation of the patient at later stages of illness was common.