Implementation of a Stewardship Initiative on Respiratory Viral PCR ‐based Antibiotic Deescalation

ConclusionA third of patients receiving broad ‐spectrum antibiotics with a positive RV PCR had an opportunity for antimicrobial optimization, although this did not translate into a significant impact on the time to antibiotic deescalation or overall antibiotic use. Combination of RV PCR results with biomarkers to rule out bacterial coinfectio ns and chest radiographic findings may help enhance the likelihood of accepted antibiotic deescalation recommendations and represents an area of future research.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research

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Officials in China’s Hubei province revealed Thursday that new cases of COVID-19 had surged nearly 10-fold from the day before—reversing days of declines that experts said were a positive sign for the containment of the virus. The number of deaths increased dramatically, as well, to 242. The jump in new cases—more than 14,800 in the province at the epicenter of the outbreak—is due to a change in the criteria for counting diagnoses of the virus. Observers say this could be a step in the right direction and lead to a better picture of the situation in the province at the epicenter of the outbreak. Ho...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized China COVID-19 onetime overnight Source Type: news
CONCLUSIONS: Higher levels of water service coverage were associated with lower incidence rates of visits for several infectious disease categories. These associations were more pronounced for communities with piped water service compared to vehicle-hauled water service. PMID: 32058938 [PubMed - as supplied by publisher]
Source: International Journal of Hygiene and Environmental health - Category: Environmental Health Authors: Tags: Int J Hyg Environ Health Source Type: research
RARITAN, NJ, February 10, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of DARZALEX® (daratumumab) in combination with Kyprolis® (carfilzomib) and dexamethasone (DKd) for relapsed/refractory multiple myeloma. The sBLA is supported by results from the Phase 3 CANDOR study, which compared treatment with DKd to carfilzomib and dexamethasone (Kd) in patients with multiple myeloma who relapsed after one to three prior lines of therapy. “Wh...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Older adults who reside in long-term care facilities (LTCFs) are at particularly high risk for infection, morbidity and mortality from pneumonia and influenza (P&I) compared to individuals of younger age and t...
Source: BMC Geriatrics - Category: Geriatrics Authors: Tags: Research article Source Type: research
AbstractWith the expanding use of molecular assays, viral pathogens are increasingly recognized among critically ill adult patients with community-acquired severe respiratory illness; studies have detected respiratory viral infections (RVIs) in 17 –53% of such patients. In addition, novel pathogens including zoonotic coronaviruses like the agents causing Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the 2019 novel coronavirus (2019 nCoV) are still being identified. Patients with severe RVIs requiring ICU care present typically with hypoxemic respiratory failure. Oseltamivir is ...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
In this study, a novel DNA-based bioassay was developed to the monitoring of Haemophilus influenza genome in human plasma samples using binding of pDNA with cDNA. DNA hybridization strategy was used to investigation of DNAs binding. For this purpose, silver nanoparticle doped graphene quantum dots inks functionalized by D-penicillamine (Ag NPs-DPA-GQDs) were synthesized and deposited on the surface of glass carbon electrode (GCE). Also, gold nanoparticles functionalized with cysteamine (CysA-AuNPs) were deposited on the surface of the Ag-DPA-GQDs modified GCE. Afterward, thiolated DNA probe was immobilized on the surface o...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
It took eight hours for a doctor to see Wu Chen’s mother after she arrived at the hospital. Eight days later, she was dead. The doctor was “99% sure” she had contracted the mysterious pneumonia-like illness sweeping China’s central city of Wuhan, Wu says, but he didn’t have the testing kit to prove it. And despite the 64-year-old’s fever and perilously low oxygen levels, there was no bed for her. Wu tried two more hospitals over the next week, but all were overrun. By Jan. 25, her mother was slumped on the tile floor of an emergency room, gasping for air, drifting in and out of conscious...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized 2019-nCoV China Source Type: news
AbstractThe aim of this study is to evaluate the impact of early (within 2  days after disease onset) neuraminidase inhibitor (NAI) administration on clinical outcomes in patients with laboratory-confirmed influenza B-related pneumonia (FluB-p). This was a multicenter study conducted from 1 January 2013 to 1 May 2019. Data of immunocompetent adult and adolescent FluB-p pa tients hospitalized at five different teaching hospitals in China were retrospectively collected, including demographic and clinical features as well as clinical and treatment outcomes. Univariate and multivariate logistic regression analyses were pe...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
It's too soon to know for sure how the tale of the novel coronavirus will play out,but at this point we have a pretty good idea. A stipulation in both of the scenarios at the linked essay is that yeah, it gets loose into the wild and eventually can show up anywhere in the world. I think that's pretty much definitely going to happen if it hasn't already.Scenario number 1, and most likely, in my view, it will just be one more virus that causes what amounts to a common cold and in a few people who are otherwise debilitated goes on to be complicated by pneumonia. In that case, for a year or two it will circulate as a novel vir...
Source: Stayin' Alive - Category: American Health Source Type: blogs
Once in a very rare while, a single, serious challenge consumes the attention of the entire world. We are living through one such period today as countries and communities come together to end the new coronavirus outbreak. This virus, provisionally known as the “2019-novel coronavirus,” has, as of 3 February 2020, spread to 24 countries, with over 17,000 people being infected to date, 99% of them in China. The limited numbers of cases elsewhere around the world – just 153 so far – show that efforts to contain the virus in China are curbing its global spread, alongside the detection and clinical care...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health ideas Source Type: news
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