Meta-analysis of Platelet Lymphocyte Ratio as A Prognostic Factor for 
Non-small Cell Lung Cancer

Background and objective Current research shows that platelet to lymphocyte ratio (PLR) has important prognostic value in renal cell carcinoma, esophageal cancer, gastric cancer, liver cancer and colon cancer. The aim of the study is to evaluate the prognostic value of PLR in non-small cell lung cancer (NSCLC) through meta-analysis. Methods Literature search for PubMed, EMBASE, Web of Science, Medline, Cochrane Library, China National Knowledge Internet (CNKI), China Biomedical Medicine disc (CBMdisc), VIP, Wanfang Database using computer electronic system to study the association between PLR and overall survival (OS) and disease-free survival (DFS). Each eligible study data is extracted and a meta-analysis is performed using the hazard risk (HR) and 95% confidence interval (95%CI) to assess the prognostic value of PLR, the time limit for the search is to build the library until November 2018. Results We include a total of 15 research literatures involving 5,524 patients for meta-analysis. According to the results of the meta-analysis: The OS of the higher PLR group is significantly lower than that of the lower PLR group (HR=1.69, 95%CI: 1.45-1.97, P
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research

Related Links:

Publication date: Available online 14 October 2019Source: Food ChemistryAuthor(s): Jianghao Sun, Craig S. Charron, Janet A. Novotny, Bing Peng, Liangli Yu, Pei ChenAbstractBroccoli is a popular brassica vegetable and its consumption may decrease the occurrence of cancer in certain populations. To gain insight into the metabolites that may induce physiological responses to broccoli intake, a non-targeted metabolomic approach and a targeted approach for analysis of glucosinolate metabolites were developed using high resolution accurate mass spectrometry. A human study was conducted in which 6 subjects consumed a single meal ...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 13 October 2019Source: Advances in Biological RegulationAuthor(s): Veronica Balatti, Carlo M. CroceAbstractWe established that loss of miR-15a/16–1 genes on chromosome 13q14 is the most common alteration in Chronic Lymphocytic Leukemia (CLL) and that miR-15/16 are crucial negative regulator of BCL-2, an antiapoptotic gene overexpressed in most CLLs and in many other malignancies. We have also shown that miR-15/16 target ROR1, a cell surface receptor for Wnt5a which can enhance growth/survival of CLL cells. Interestingly, ROR1 is expressed by many cancers, but not by normal adult tis...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: 1 December 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 184Author(s): Maosheng Xu, Kunsong Zhang, Yubing Liu, Jie Wang, Ke Wang, Yuanqing ZhangAbstractThe treatment of cancer has always been a worldwide problem. The combination of chemotherapy and other therapies would be a promising therapy strategy. Photothermal therapy (PTT) does not cause serious side effects and has dual control of time and space, which was considered to be a good method for combination with chemotherapy. Here, we modified multifunctional nanosheets based on in-situ gold nanoparticles (Au NPs) grown molybdenum disulfide...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 13 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Chaonan Yang, Qingfu Guo, Yan Lu, Bin Zhang, Guangming NieABSTRACTA novel “signal-on” electrochemiluminescence (ECL) immunosensor is constructed by using Au nanoparticle/graphene quantum dots-poly(etherimide)-graphene oxide (AuNP/GQDs-PEI-GO) composite as a probe to detect prostate-specific antigen (PSA). GQDs and AuNP are modified onto the PEI-GO through amide bond and electrostatic interaction sequentially. Poly(indole-6-carboxylic acid)/flower-like Au nanoparticles (PICA/FGNs) composites with satisfactory co...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 14 October 2019Source: Chinese Chemical LettersAuthor(s): Minghao Wu, Qing Chen, Yingdi Wang, Yulei Li, Xia Zhao, Qi ChangAbstractHYL derived from the venom of the solitary bee Hylaeus signatus (Hymenoptera: Colletidae) is an α-helical antimicrobial peptide with 16 residues. To explore whether HYL can be applied in anti-tumor therapy, we synthesized HYL and further modified its structure by using a solid-phase synthesis method, and then evaluated their antitumor activities. Firstly, we identified the key residues of HYL by alanine scanning strategy, and then a series of stapled pept...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
J. Anal. At. Spectrom., 2019, Accepted Manuscript DOI: 10.1039/C9JA00300B, PaperAnna Fedrigo, Davide Raspino, Francesco Grazzi, Antonella Scherillo In this work Neutron Diffraction (ND) and Neutron Resonance Transmission Imaging (NRTI) are applied for the material characterization of composite artefacts, two bimetallic sword fragments from ancient China, in order... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Anal. At. Spectrom. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 13 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Kubra Bilici, Abdullah Muti, Alphan Sennaroğlu, Havva Yagci AcarAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) have been recently recognized as highly efficient photothermal therapy (PTT) agents. Here, we demonstrate, for the first time to our knowledge, dose and laser intensity dependent PTT potential of small, spherical, 3-aminopropyltrimethoxysilane coated cationic superparamagnetic iron oxide nanoparticles (APTMS@SPIONs) in aqueous solutions upon irradiation at 795 nm. Indocyanine gr...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Months after closing a new $3.5 million financing round, Philadelphia-based Mebias Discovery said it will deploy the funds to expand its pipeline of new drug candidates targeting gastrointestinal and inflammatory disorders. The Philadelphia Business Journal first reported on the financing in July. Medias confirmed Monday the financing was led by Viva Biotech of China and Sprout BioVentures of Boston. The company was founded in 2016 by researchers from Janssen Pharmaceuticals and Merck. It has since…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
It will have a fully staffed emergency room, about 10 observation beds plus, in Hempfield's case, an AHN cancer center and other physician offices.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
This study aimed to investigate whether combining anti-PD-L1 Atezolizumab with BEV may have a synergistic effect and enhance the efficacy of both treatments in cisplatin resistant epithelial ovarian cancer (CREOC). We retrospectively analyzed 124 epithelial ovarian cancer (EOC) patients from Gynecologic Oncology Department of Tianjin Cancer Hospital between January 2013 and June 2018, who all were diagnosed with cisplatin resistance due to progressing
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | China Health | Colon Cancer | Colorectal Cancer | Computers | Databases & Libraries | Esophagus Cancer | Gastric (Stomach) Cancer | Gastroenterology | Hepatocellular Carcinoma | Internet | Kidney Cancer | Liver | Liver Cancer | Lung Cancer | Non-Small Cell Lung Cancer | Renal Cell Carcinoma | Science | Study | Urology & Nephrology