Sex and Hormonal Status Influence the Persistence of Addiction in Animal Models

In this issue of Biological Psychiatry, Nicolas et  al. (1) add to a growing literature demonstrating the importance of sex and gonadal hormones in the development of substance use disorders. Their study focused on the incubation of cocaine craving in male versus female rats tested at different estrous cycle phases. Overall, they showed that estrou s cyclicity significantly altered cocaine craving (or seeking) after a drug-free period. From a translational perspective, these incubation of craving and self-administration procedures model several key features of human substance use.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Early Career Investigator Commentary Source Type: research

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CONCLUSION: Cocaine use may be responsible for asthma onset, acute asthma exacerbations (which may require intubation and invasive ventilation) or death related to asthma. Cocaine use must be systematically considered in the case of asthma exacerbation and practitioners must help cocaine users to stop their consumption. PMID: 31201016 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Abstract Dopaminergic (DA) neurons are involved in many critical functions within the central nervous system (CNS), and dopamine neurotransmission impairment underlies a wide range of disorders from motor control deficiencies, such as Parkinson's disease (PD), to psychiatric disorders, such as alcoholism, drug addictions, bipolar disorders, schizophrenia and depression. Neural stem cell-based technology has potential to play an important role in developing efficacious biological and small molecule therapeutic products for disorders with dopamine dysregulation. Various methods of differentiating DA neuron...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
ConclusionThis study demonstrates a significant difference in the academic performance of medical students as influenced by social media usage. Medical educators are urged to frame guidelines for using social media for educational purposes that will help improve the academic performance of the students.
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
Publication date: Available online 14 June 2019Source: The Lancet HIVAuthor(s): Alessandro Livelli, Florin Vaida, Ronald J Ellis, Qing Ma, Micol Ferrara, David B Clifford, Ann C Collier, Benjamin B Gelman, Christina M Marra, Justin C McArthur, J Allen McCutchan, Susan Morgello, Ned Sacktor, David M Simpson, Igor Grant, Scott L Letendre, Ian Abramson, Muhammad T. Al-Lozi, Sarah L. Archibald, J. Hampton AtkinsonSummaryBackgroundFew large projects have evaluated the factors that influence the HIV RNA concentrations (viral load) in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) over time. We aimed to determine t...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Authors: Bhui KS, Byrne P, Goslar D, Sinclair J Abstract SummaryAddictions are challenging health and social problems that need to be addressed to preserve and promote good mental health and ensure that individuals within society lead healthy and productive lives. Tackling addictions is complex and requires communities, public health, specialist services, and local and national government to act in unison and implement evidence-based interventions. This editorial raises systemic issues that need attention and proposes a range of systemic options.Declaration of interestK.S.B. is Editor-in-Chief of the British Journa...
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
CONCLUSION: The results indicate that internet gaming problems might be affected by environmental factors and it is recommended that gaming activity is substituted with physical activity, extracurricular classes, books, and music. PMID: 31197982 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Acid, or LSD, is a drug that can cause hallucinations and feelings of euphoria. In this article, learn how long these effects last and how long the drug stays in the human body.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alcohol / Addiction / Illegal Drugs Source Type: news
Publication date: Available online 14 June 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): William J.A. Eiler, Scott D. Gleason, Jodi L. Smith, Jeffrey M. WitkinAbstractOne of most formidable problems in the treatment of addiction is the high rate of relapse. The discovery of medicines to help mitigate relapse are aided by animal models that currently involve weeks of training and require surgical preparations and drug delivery devices. The present set of experiments was initiated to investigate a rapid 8-day screening method that utilizes food instead of intravenous drug administration. Male Sprague-Dawley ra...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 14 June 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Adebobola Imeh-Nathaniel, Vasiliki Orfanakos, Leah Wormack, Robert Huber, Thomas I. NathanielAbstractFundamental signs of epigenetic effects are variations in the expression of genes or phenotypic traits among isogenic mates. Therefore, genetically identical animals are in high demand for epigenetic research. There are many genetically identical animals, including natural parthenogens and inbred laboratory lineages or clones. However, most parthenogenetic animal taxa are very small in combined epigenetic and drug addicti...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
AbstractThere are 415,000 children in foster care in the USA. Many of those children will turn 18 before being adopted, meaning they will “age-out” and essentially be on their own as adults. We wanted to see if formal mentoring programs improved outcomes for those aging out of foster care and the Journey Up Mentorship Program in Salt Lake City offered such a program. Forty-nine youth who had aged out of foster care with the help o f mentors were surveyed and found they scored significantly higher in their ability to get jobs and were less at risk for addiction, homelessness, and incarceration compared to data f...
Source: Global Social Welfare - Category: International Medicine & Public Health Source Type: research
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