What Causes Macrocephaly?

Discussion “Macrocephaly is defined as [an occipitofrontal circumference or head circumference, OFC ] of> 2 standard deviations above the mean or above the 97th percentage for a given age, and gender, or when serial measurement shows progressive enlargement, crossing of one or more major percentiles, or when there is an increase in OFC> 2 cm/month in the first 6 months of life.” Megalencephaly is enlargement of the brain parenchyma. The OFC should be measured using a non-elastic tape which surrounds the head along the line of the glabella and posterior occipital protrusion. There are ethnic differences for head circumferences so the growth chart that best matches the child’s family heritage should be used. A review of the best growth charts can be found here. General averages for OFC increase are: Average at birth = ~35 cm 0-3 months = 2 cm/month (average 3 month old is ~ 41 cm) 0-1 year = 1 cm/month (average 1 year old is ~ 47 cm) > 1 year = only another 8 cm total (average adult is ~ 55 cm) A review of the other growth parameters can be found here. Patients should be evaluated for developmental delay, signs of intracranial infection or trauma, syndromic features, and family history of cutaneous or neurological abnormalities. Children with non-full fontanels, normal mentation and no signs of developmental delay are more likely to have familial, isolated or benign enlargement of the subarachnoid space. Changes in mentation, developmental delay a...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Conclusions Exercise training combined with multinutrient supplementation had a limited effect on ameliorating the adverse musculoskeletal consequences of ADT, likely related to the modest intervention adherence.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Conclusions In conclusion, using contemporary methods to assess muscle architecture and calculate EFFPCSA did not enhance the muscle strength–size association. For understanding/monitoring muscle size, the major determinant of strength, these findings support the assessment of muscle volume, which is independent of architecture measurements and was most highly correlated with strength.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
Conclusion Chronic exercise seems to prime the central nervous system for acute, intensive bouts of exercise. Our findings indicate a possible relationship between cognitive performance in high-demand tasks and retinal vasculature and support the idea of a neuroplastic effect of exercise.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
September 19, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced preliminary results from the Phase 1b CHRYSALIS-2 (NCT04077463) study evaluating RYBREVANT® (amivantamab-vmjw) in combination with lazertinib in the treatment of patients with non-small cell lung cancer (NSCLC) characterized by epidermal growth factor receptor (EGFR) exon 19 deletion or L858R mutations whose disease had progressed after treatment with osimertinib and platinum chemotherapy.[i] While previously reported results have demonstrated durable responses with RYBREVANT® in combination with ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
September 19, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced a new analysis from the CHRYSALIS (NCT02609776) study evaluating RYBREVANT® (amivantamab-vmjw) monotherapy and a combination regimen with lazertinib in advanced non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations who progressed after osimertinib.[1] The analysis showed higher activity and longer duration of response (DOR) in patients treated with the combination therapy, demonstrating the potential benefit of targeting the extracellular (outer) and cataly...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Weight loss can be aided by a number of vitamins and supplements, research finds.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Weight Loss Source Type: blogs
Good sources of vitamin B12 include fish, poultry, eggs and low-fat milk.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Nutrition Source Type: blogs
A SMALL degree of cognitive decline is expected of stroke sufferers after an incident, but the disruption that COVID-19 has inflicted on health services has left thousands of stroke patients suffering severe complications, including disability. One modifiable lifestyle habit could hike the chances of succumbing to a stroke.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients. NANOG Expression versus Cellular Senescence https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/ Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living an...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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