Acute lymphoblastic leukemia in a nine-year-old girl with isodicentric chromosome 15 syndrome

Publication date: Available online 18 May 2019Source: Cancer GeneticsAuthor(s): Roberto Antonucci, Nadia Vacca, Elisa Ghisu, Gloria Acquaviva, Carlo Cosmi, Anna Maria Marinaro, Cristian Locci, Claudio FozzaAbstractIsodicentric chromosome 15, also called idic(15), is a rare chromosomal abnormality resulting from inverted duplication of proximal 15q. It is associated with specific clinical findings such as early central hypotonia, developmental delay, cognitive dysfunction, autism spectrum disorders, and seizure. Herein we describe a case of a girl with idic(15) syndrome who developed acute lymphoblastic leukemia (ALL) at the age of 9 years. Our case suggests a possible correlation between idic(15) and ALL, and possible functional links between these two conditions.
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research