Effect of omega-3 supplementation on Expanded Disability Status Scale and Inflammatory Cytokines in multiple sclerosis: A systematic review and meta-analysis of randomized controlled trials.

Effect of omega-3 supplementation on Expanded Disability Status Scale and Inflammatory Cytokines in multiple sclerosis: A systematic review and meta-analysis of randomized controlled trials. CNS Neurol Disord Drug Targets. 2019 May 15;: Authors: Sedighian M, Djafarian K, Dabiri S, Abdollahi M, Shab-Bidar S Abstract Recent trial studies have shown that omega-3 supplementation can beneficially improve Expanded Disability Status Scale (EDSS) which considered as a gold standard for measuring disability and disease severity in multiple sclerosis (MS) patients as well as reducing neuroinflammation. The present systematic review and meta-analysis aimed to evaluate the effect of omega-3 supplementation on EDSS and cytokines in MS. We performed a systematically search on Pubmed, Scopus and Cochrane Library up to October 2018. Studies were reviewed based on Cochrane handbook and preferred reporting items for systematic reviews and meta-analyses (PRISMA). Weighted mean difference (WMD) with 95% confidence intervals (CI) were pooled using random effects model in order to compare the effects of omega-3 with placebo. Among 4 trials, omega3 supplementation had no significant effect on EDSS scale (WMD: -0.07; 95% CI: -0.27 to 0.13; P=0.50) as well as serum levels of IL-1β (WMD: -7.67; 95% CI: -23.31 to 7.97; P=0.34) and IL-6 (WMD: -153.57; 95% CI: -455.36 to 148.23; P=0.32) but omega-3 significantly reduce TNF-α concentration (WMD: -16.76; 95% CI:...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research