Immunotherapeutic Strategies for Cutaneous Squamous Cell Carcinoma Prevention in Xeroderma Pigmentosum.
This article is protected by copyright. All rights reserved. PMID: 31102460 [PubMed - as supplied by publisher]
In conclusion, our data demonstrate the impact of the secretome of cancer cells on the transcription machinery of the cells surrounding the tumor, leading to a tumorigenic cell fate. These observations underline the influence of mTOR on cSCC and might bear significance for novel strategies in cancer therapy.
Authors: Kircik LH Abstract Actinic keratosis (AK) represents one of the most common diagnoses in our dermatology practices. The incidence of AK lesions continues to rise, along with that of non-melanoma skin cancers. Numerous risk factors have now been implicated, including chronic sun exposure, history of sunburns, fair skin, advanced age, male gender, and immunosuppression. Although an individual lesion’s likelihood of progression to malignancy remains very low, AKs seldom occur in isolation. Indeed, the condition can most accurately be described as a “field disease”, with a mix of clinical and...
CONCLUSION: Anatomical subsites, specifically scalp/neck tumors, tended to have worse overall survival. Positive final margins tended to indicate a worse prognosis, and overall survival and recurrence were not significantly different among patients who underwent radical surgical resection compared to soft tissue resection. PMID: 31091995 [PubMed - as supplied by publisher]
CONCLUSIONS: Our large study suggests that prevention of melanoma in NMSC patients is mandatory, especially for patients which develop a NMSC under 40 years of age. PMID: 31042854 [PubMed - as supplied by publisher]
Conclusions: Our results underestimate the direct costs of nmsc because inpatient services and non-physician costs were not included in the calculations. The present research represents a first step in understanding the cost burden of nmsc in Saskatchewan. PMID: 31043813 [PubMed - in process]
The authors discuss the potential use and limitations of immunotherapy among patients with squamous cell cancer, basal cell carcinoma, and other skin cancers.
Skin cancer is the most common form of cancer in the United States. Research estimates that nonmelanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma, affects more than 3 million Americans a year. The incidence of both non-melanoma and melanoma skin cancers has been increasing over the past decades. Fortunately, most NMSC lesions are detected at an early stage that is amenable to very effective local therapy and thus are highly curable. Various therapeutic modalities are currently being used to treat these tumors, including surgery, topical treatments and radiotherapy.
Photodynamic therapy (PDT) is used for the treatment of several types of Non-Melanoma Skin Cancer (NMSC) although sometimes resistant cells responsible for the relapses may appear after treatment. Normal differentiated cells depend primarily on mitochondrial oxidative phosphorylation to generate energy, but cancer cells change this metabolism to an aerobic glycolysis (Warburg effect), which could influence in the response to antitumor drugs. Here, we have evaluated the expression of different proteins implicated in the energetic metabolism in the resistance to PDT of squamous cell carcinoma (SCC) in vitro and in vivo.
Australia is the ideal place to study genomic drivers of sun induced cancers. The primary risk factor for non-melanoma skin cancer development is a combination of high lifetime exposure to ultraviolet light and a predominantly fair-skinned population that lacks the photoprotective effect of melanin in darker skin types. While a number of other factors play a role, 95% of skin cancers are related to sun exposure. We recruited 25 volunteers and collected 1x cutaneous squamous cell carcinoma (cSCC), 2x actinic keratosis samples (AK), 1x photo damaged (PD) skin samples and 1x blood sample for whole exome sequencing on 24xSCC, 50xAK and 25xPD.
Background: The cutaneous squamous cell carcinoma is a malignant tumor that occurs in the epidermis or accessory cells. It accounts for about 20% of all non-melanoma skin cancers and is the second most common skin malignancy. RIPK3, a member of the receptor-interacting protein kinase family, is a TNFR1-regulated transcription factor that plays an important role in cellular stress of various factors and may be involved in regulating cell cycle, inhibiting apoptosis, and regulating programmed cell death, etc.