Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin ‐two cases

ConclusionMetformin may be a candidate drug for treatment of several types of symptoms in individuals with FXS.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Publication date: Available online 18 November 2019Source: Saudi Journal of Biological SciencesAuthor(s): V. Duraipandiyan, R. Balamurugan, Naif Abdullah Al-Dhabi, T. William Raja, P. Ganesan, B. Ahilan, M. Valan Arasu, S. Ignacimuthu, Galal Ali EsmailAbstractBorassus flabellifer L. is a tall palm traditionally used for its stimulating, diuretic and anti-inflammatory activities; it is rich in fibers and various pharmacologically important secondary metabolites. The present study was undertaken to evaluate the antidiabetic effects of Borassus flabellifer fruit methanol extract (BF-M) on diabetic rats induced with High Fat D...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 18 November 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xiao Chang, Xiaofang Li, Xurong Qiao, Kun Li, Ya Xiong, Xiao Li, Tianchao Guo, Lei Zhu, Qingzhong XueAbstractIt is imperative to explore an accurate ppb-level acetone sensor for noninvasive detection of diabetes. In this work, two dimensional p-type MoS2 nanosheets are introduced on the surface of p-type ZnO derived from metal-organic frameworks (MOFs) to produce ZnO@MoS2 core/shell heterojunctions as a novel acetone sensor, showing a great enhancement of acetone response, about two orders of magnitude than that of pure Z...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: November 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 11Author(s): Wei-Feng LI, De-Wen YAN, Yu JIN, Hai-Yan LI, Min MA, Zheng-Zhi WUAbstractDiabetes mellitus (DM) is a metabolic disorder disease characterized by hyperglycemia. Long-term physiological hyperglycemia will aggravate the degree of non-enzymatic glycation (NEG) proteins. Because the abnormal changes of non-enzymatic process can cause a series of pathological variation, NEG proteins have attracted more and more attention. Mass spectrometry (MS) is an indispensable and powerful analytical tool for the qualitative and quan...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 18 November 2019Source: TechnovationAuthor(s): Jonathan D. LintonAbstractGeneralizability is the goal for scientists (both social and natural). In the social sciences invoking generalizability is more problematic as it is often based on assessment of a mainstream population, but may not apply to groups outside of the mainstream. This is a significant challenge to developing appropriate policy and interventions suitable for Other groups. An example is given of how this concern was overcome through consideration of the Voice Of the Customer (VOC) and utilizing cognitive maps to consider the...
Source: Technovation - Category: Science Source Type: research
Publication date: Available online 18 November 2019Source: Regional Science and Urban EconomicsAuthor(s): Jiajun LuAbstractThe paper examines the relationship between climate amenities and locational choices in retirement. Using data from 2017 release of the American Community Survey, I construct a household residential location choice model and value climate amenities from the trade-offs among housing cost, climate amenities, and other locational attributes in a metropolitan statistical area (MSA). On average, a retired household is willing to pay $1209 for a 1○C drop in average summer temperature, $1114 for a 1○C inc...
Source: Regional Science and Urban Economics - Category: Science Source Type: research
We present a review of the classifications, pathophysiology, and evidence-based guidelines for planning and preventive measures, as well as best practice recommendations for both routine and urgent therapeutic management of diabetes and glycemic complications. These recommendations are graded based on the quality of supporting evidence and balance between the benefits and risks or burdens for each recommendation.
Source: Wilderness and Environmental Medicine - Category: Environmental Health Source Type: research
This study aimed to evaluate long-term patency of the RA conduit compared to the SV conduit for off-pump CABG, and to screen the independent predictors of long-term RA graft failure.Patients
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
AbstractPurposeMental well-being among community-dwelling individuals with type 2 diabetes has not been well established. The primary objective was to evaluate the change in the mental well-being of individuals with diabetes. The secondary objective was to evaluate the association between changes in mental well-being and perceived health over 6  months, and any interacting factors in this association.MethodsThis was a prospective, multicenter study. Community-dwelling individuals aged  ≥ 21 years with type 2 diabetes were invited to meet with community pharmacists monthly for 6 months. Indiv...
Source: Quality of Life Research - Category: Health Management Source Type: research
Publication date: Available online 18 November 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Karam AboudehenAbstractThe mechanistic target of rapamycin (mTOR) is a major signaling hub that coordinates cellular and organismal responses, such as cell growth, proliferation, apoptosis, and metabolism. Dysregulation of mTOR signaling occurs in many human diseases, and there are significant ongoing efforts to pharmacologically target this pathway. Long noncoding RNAs (lncRNA), defined by a length > 200 nucleotides and absence of a long open-reading-frame, are a class of non-protein...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - Category: Genetics & Stem Cells Source Type: research
Metformin, the most widely used drug to treat type 2 diabetes, could potentially be used to treat symptoms of Fragile X syndrome, an inherited form of intellectual disability and a cause of some forms of autism.
Source: ScienceDaily Headlines - Category: Science Source Type: news
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