Establishing research priorities for chronic kidney disease of non-traditional causes in Central AmericaDetermina ção de prioridades em pesquisa da doença renal crônica associada a causas não tradicionais na América Central.

Conclusions: In addition to etiological factors, great importance was assigned to aspects related to the health system response, including service delivery approaches, human resources, funding, and occupational and environmental aspects. PMID: 31093042 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research

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Publication date: Available online 8 June 2019Source: SexologiesAuthor(s): M. OhayonSummaryImprovements in the prognosis for HIV infection and the impact of biomedical strategies for the prevention of transmission have created very specific situations for men who live with HIV within the homosexual minorities. Originally focused on their duty in preventing transmission, the issue at stake gradually moved towards one of power, with the HIV-infected person, the hero/martyr of the 1980s and 1990s, becoming the hero who has vanquished the fear of Aids. Undetectable viral load, the standard of current treatment, makes the indiv...
Source: Sexologies - Category: Sexual Medicine Source Type: research
Publication date: Available online 18 June 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Lu Dai, Abdul Rashid Qureshi, Anna Witasp, Bengt Lindholm, Peter StenvinkelAbstractChronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular disease, systemic inflammation, muscle wasting and frailty. The predominant early vascular ageing (EVA) process mediated by medial vascular calcification (VC) results in a marked discrepancy between chronological and biological vascular age in CKD. Though the exact underlying mechanisms of VC and EVA are not fully elucidat...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Authors: Sabbatani S, Fiorino S, Manfredi R Abstract In past centuries, epidemics, the scourge of humankind, caused pain, anger, uncertainty of the future, social as well as economic disorder and a significant impact on their victims, involving also their spiritual sphere. The latter effect led to undoubted effects on participation in the religious and social life of communities. The custom of preparing artistic votive expressions has been lost in the mists of time and evidence of ex voto gifts, offered by believers to pagan gods, has been found in prehistoric archaeological sites. Furthermore, several finds from t...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Authors: Sanchez ML, Vallina-Victorero MJ, Bachiller MR, Arbizu R, Llaneza E, Rozada S, Eiros JM Abstract Increasing bacterial resistance is strictly correlated to the increasing use of antibiotics, currently constituting a public health problem. The aim of this study was to describe the consumption of antibiotics in Asturias, an autonomous community in northwestern Spain, and compare the results obtained with data from elsewhere in Spain and other European countries. A descriptive study was carried out on the use of antibacterial drugs for systemic use, ATC code J01 in Asturias in 2011-2015. Data were obtained fro...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. The first cases were reported in Malaysia and Singapore in 1998, when affected individuals presented with severe febrile encephalitis. Since then, much has been identified about this virus. These single-stranded RNA viruses gain entry into target cells via a process k...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Publication date: Available online 18 June 2019Source: EpidemicsAuthor(s): Samuel Alizon, Carmen Lía Murall, Emma Saulnier, Mircea SofoneaAbstractParasite genetic diversity can provide information on disease transmission dynamics but most mathematical and statistical frameworks ignore the exact combinations of genotypes in infections. We introduce and validate a new method that combines explicit epidemiological modelling of coinfections and regression-Approximate Bayesian Computing (ABC) to detect within-host interactions. Using a susceptible-infected-susceptible (SIS) model, we show that, if sufficiently strong, wi...
Source: Epidemics - Category: Epidemiology Source Type: research
Publication date: Available online 17 June 2019Source: American Journal of Kidney DiseasesAuthor(s): Anna Burgner, Michelle A. HladunewichWomen with chronic kidney disease (CKD) are faced with complex decisions and significant challenges during their reproductive years. Contraceptive choices have a variety of side effects that can disproportionately affect women with CKD, limiting choice. CKD itself and the therapies needed to treat severe disease can affect future fertility. When conception is desired, young women with CKD must plan meticulously because an ill-timed pregnancy can result in disease progression or flare and...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: Available online 16 June 2019Source: Journal of Food Composition and AnalysisAuthor(s): Mª de Lourdes Samaniego-Vaesken, Teresa Partearroyo, Andrea Cano, Rafael Urrialde, Gregorio Varela-MoreirasAbstractAdded sugars encompass a number of ingredients used to improve flavour, texture and many characteristics from food products. Their increased intake from foods and beverages has been described by several studies and public health authorities recommend reducing their consumption. The use of low and no-calorie sweeteners (LNCS) has acquired a central role as partial or total substitutes for these controv...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
Because of the less-than-robust response to therapy and impact on choice of optimal chemotherapy and prognosis, chronic kidney disease has drawn attention in the treatment of multiple myeloma, a malignant hematologic disorder that can produce significant amounts of monoclonal immunoglobulin free light chains (FLCs). These low-molecular-weight proteins are relatively freely filtered through the glomerulus and are reabsorbed by the proximal tubule. The present study demonstrated that during the process of metabolism of immunoglobulin FLCs, ROS activated the STAT1 pathway in proximal tubule epithelium. STAT1 activation served...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionsRenal biopsies, while not commonly performed in children with SCD, were universally abnormal. Outcomes were poor in this cohort of patients despite a variety of post-biopsy interventions. Effective early intervention to prevent chronic kidney disease (CKD) is needed to reduce morbidity and mortality in children with SCD.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
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