Impact of Biliopancreatic Limb Length (70 cm vs 120 cm), with Constant 150 cm Alimentary Limb, on Long-Term Weight Loss, Remission of Comorbidities and Supplementation Needs After Roux-En-Y Gastric Bypass: a Prospective Randomized Clinical Trial

ConclusionA RYGB with 120  cm BPL does not achieve greater weight loss or remission of comorbidities than a RYGB with 70 cm BPL but is associated with greater deficiencies of vitamin B12, vitamin A, and folic acid.Trial RegistrationClinicalTrials.gov Identifier NCT03607305.https://clinicaltrials.gov/.
Source: Obesity Surgery - Category: Surgery Source Type: research

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ConclusionComparing the 5-year success rate of these two techniques, LRYGB seems to be superior to LSG, with lower weight regain and higher weight loss. The short- and long-term effects of two procedures on remission of comorbidities were comparable.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionA high-level of suspicion is required to suspect, diagnose and treat post-RYGB complications. A bariatric on-call rota with appropriately trained personnel is essential.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsOAGB is a valid alternative for long-term weight loss and remission of comorbidities in childhood and adolescence. No cases of malnutrition or growth disorders were observed.
Source: Obesity Surgery - Category: Surgery Source Type: research
From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy Jens Juul Holst* Department of Biomedical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Researchers have been looking for insulin-stimulating factors for more than 100 years, and in the 1960ties it was definitively proven that the gastrointestinal tract releases important insulinotropic factors upon oral glucose intake, so-called incretin hormones. The first significant factor identified was the duodenal glucose-dependent insulinotropic polypeptide, GIP, wh...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusions: Bariatric surgery appears to be capable of partially reversing the obesity-related epigenome. The identification of potential epigenetic biomarkers predictive for the success of bariatric surgery may open new doors to personalized therapy for severe obesity. Introduction Obesity is currently a huge healthcare problem, worldwide, and is a risk factor for several diseases such as type 2 diabetes (T2D), cardiovascular disease and cancer (1). As the prevalence of obesity reaches pandemic proportions, this metabolic disease is estimated to become the biggest cause of mortality in the near future (2). In fact,...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionThis is the first report from the MENA region on the long-term outcomes of RYGB in the treatment of type II DM. The results are similar to those in the international literature.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
ConclusionsRYGB was superior in %EWL for SSO and SO at 12  months. However, regarding at 24 months, RYGB was equal to SG, which is from a meta-analysis and cannot be seen as a definitive conclusion.
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractIntroduction/PurposeMetabolic syndrome is commonly demonstrated in patients with morbid obesity undergoing bariatric surgery. The purpose of this study was to determine the effect of metabolic syndrome on morbidity and mortality following bariatric surgery.Materials and MethodsThe National Surgical Quality Improvement Program (NSQIP) dataset was queried for patients who underwent bariatric surgical procedures between 2012 and 2014. Patient demographics, comorbid conditions, bariatric procedure type, and postoperative complications were analyzed. Metabolic syndrome was defined as having a body mass index> &thinsp...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
AbstractIntroductionThe data on the role of OAGB in super obese patients and its direct comparison with LSG in super obese patients is scarce.ObjectivesTo compare weight loss, impact on comorbidities and nutritional parameters between LSG and OAGB in super obese patients.MethodsProspectively collected data of 75 matched patients with BMI  >  50, who underwent either laparoscopic sleeve gastrectomy (LSG) or one anastomosis gastric bypass (OAGB), was analyzed retrospectively. Percentage excess weight loss at 1 year and impact on comorbidities were compared in both the groups.ResultsBoth the groups were ...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionAlthough the sample size is small to draw definitive conclusions, bariatric surgery in patients 65  years or older seems to be safe, with similar outcomes and complication rates as in younger patients, regardless of procedure performed.
Source: Obesity Surgery - Category: Surgery Source Type: research
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