Activity of Adansonia digitata on biochemical and hematological changes in established Plasmodium berghei -infected mice

This study evaluated the efficacy ofAdansonia digitata stem bark extract on hematological and renal changes in establishedPlasmodium berghei infection in mice. Albino wistar mice were used in the study. The mice were transfected intraperitonially with an inoculum size of l  × 107 of chloroquine susceptible strain ofPlasmodium berghei-infected erythrocytes. Percentage chemosupression and packed cell volume (PCV) were determined. The antiplasmodium effects of the extracts were investigated by measuring the hemoglobin (Hb) content, white blood cell (WBC) count, and cell differentials. Severity of malaria was determined by measuring the serum creatinine, urea, and uric acid concentrations. An essential biomarker of malaria-associated disturbance in mineral homeostasis was determined by measuring the electrolyte concentrations. Administration of the extracts had effect on the growth ofPlasmodium berghei parasite in mice. The extracts showed a significant decrease in percentage parasitemia at the two doses and a significant dose-dependent increase in PCV, percentage chemosupression when administered after established infection. There was a significant decrease in hemoglobin content, neutrophil, lymphocyte, and mean corpuscular hemoglobin concentration (MCHC) in the control group followingPlasmodium berghei infection. The extract significantly reduced the WBC, platelet, monocyte count, mean corpuscular hemoglobin (MCH), and mean cell volume (MCV). Administration of the extract ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research