Whole-genome analysis of New Delhi Metallo-Beta-Lactamase-1-producing Acinetobacter haemolyticus from China
ConclusionThe NDM-1-producing A.haemolyticus coexisted multiple durg-resistant determinants. The acquisition of the blaNDM-1 gene was probably facilitated by Tn125 in this strain. Non-A.baumannii species also contain GIs.
ConclusionsThese data are valuable in providing a baseline for AMR among common bacterial pathogens in Vietnamese hospitals and to assess the impact of interventions.
ConclusionsThe genome sequence of A. baumannii L13 reported here will benefit the comparative analysis of the genus Acinetobacter, and promote further understanding of the specific genomic feature in terms of multidrug resistance in A. baumannii.
Conclusion: The majority of bacterial pathogens were resistance to various antibiotics. Judicious use of antibiotic therapy can prevent the emergence and spread of antibiotic-resistant Gram-negative bacteria. PMID: 31127910 [PubMed - in process]
ConclusionThe HAI surveillance system successfully detected and facilitated the control of theA.baumannii outbreak. Whole-genome sequencing was found to be a useful method for differentiation of phenotypically identicalA.baumannii strains from the intrahospital outbreak. Only multi-modal infection control program, including closure, temporary relocation, and renovation of the ward, restricted the outbreak.
Publication date: Available online 18 May 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Giuseppe Vittorio De Socio, Paola Rubbioni, Daniele Botta, Elio Cenci, Alessandra Belati, Riccardo Paggi, Maria Bruna Pasticci, Antonella MencacciAbstractObjectivesThe aim of the study was to evaluate a cumulative antimicrobial resistance index (ARI) as a possible key outcome measure of antimicrobial stewardship (AS) programs and as a tool to predict antimicrobial resistance (AMR) trend.MethodsAntibiotic susceptibility for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pse...
ConclusionsThe present data reporting efficacy of phage therapy in a mouse model of bacteremia support the development of phage-based drugs to manage infection due to multi-drug resistant A. baumannii and particularly XDRAB.
CONCLUSION: The high prevalence of MDR strains and the circulation of four limited clones, including ST10 (45/99), ST2 (41/99), ST3 (12/99) and ST513 (1/99), in the clinical setting highlights the importance of a rigorous infection control programme. The two-locus typing method has more discrimination than the application of each method separately and it could be applied for the rapid determination of the CC without performing MLST. PMID: 31050632 [PubMed - as supplied by publisher]
Publication date: June 2019Source: Journal of Global Antimicrobial Resistance, Volume 17Author(s): A.S. Smiline Girija, J. Vijayashree Priyadharsini, A. Paramasivam
ConclusionsTMP/SMX might be a valuable treatment option for TMP/SMX-susceptible CRAB infections. Given the very limited available treatment options, further studies assessing its effectiveness and safety are necessary.
Conclusion: New carbapenem/βLI combinations may be viable alternatives to antimicrobial combination therapy as they displayed high efficacy in vitro and in vivo. Meropenem/Avibactam and Meropenem/Relebactam should be tested on larger sample sizes with different carbapenemases before progressing further in its preclinical development. Introduction Carbapenem resistant Gram-negative bacteria have been gradually increasing in prevalence in recent years. In the United States, the latest CDC Antibiotic Resistance Threat Report indicates that Carbapenem-Resistant Enterobacteriaceae (CREs) are responsible for 9,000 a...