Absolute immature platelet count dynamics of thrombotic thrombocytopenic purpura patients with high ADAMTS13 inhibitor

Acquired/idiopathic thrombotic thrombocytopenic purpura (TTP) is manifested by auto-antibody formation to ADAMTS13 which leads to accumulation of ultra-large molecular weight von Willebrand Factor multimers, thrombocytopenia, and diffuse microvascular thrombi [1]. A recent report has given support that a TTP diagnosis should be limited to patients with ADAMTS13 deficiency secondary to autoantibody formation who mostly respond to therapeutic plasma exchange (TPE) [2].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research