Fluorine-Containing Drugs Approved by the FDA in 2018.

Fluorine-Containing Drugs Approved by the FDA in 2018. Chemistry. 2019 May 17;: Authors: Mei H, Han J, Fustero S, Medio-Simon M, Sedgwick DM, Santi C, Ruzziconi R, Soloshonok VA Abstract Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atom. In this review, we profile 17 fluorine-containing drugs approved by the FDA in 2018. The newly approved pharmaceuticals feature several types of aromatic F- and CF3-, aliphatic (CF2) substitution, offering advances in treatment of various diseases, including cancer, HIV, malarial and smallpox infections. PMID: 31099931 [PubMed - as supplied by publisher]
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research