Gellan gum incorporating titanium dioxide nanoparticles biofilm as wound dressing: Physicochemical, mechanical, antibacterial properties and wound healing studies

Publication date: Available online 18 May 2019Source: Materials Science and Engineering: CAuthor(s): Nur Arifah Ismail, Khairul Anuar Mat Amin, Fadzillah @. Adibah Abdul Majid, Mohd Hasmizam RazaliAbstractIn this work, the potential of titanium dioxide nanoparticles incorporated gellan gum (GG + TiO2-NPs) biofilm as wound dressing material was investigated. The GG + TiO2-NPs biofilm was prepared via evaporative casting technique and was characterized using FTIR, XRD, and SEM to study their physiochemical properties. The mechanical properties, swelling and water vapor transmission rate (WVTR) of biofilm was determined to comply with an ideal wound dressing material. In vitro and in vivo wound healing studies was carried out to evaluate the performance of GG + TiO2-NPs biofilm. In vitro wound healing was studied on 3 T3 mouse fibroblast cells for cell viability, cell proliferation, and scratch assay. The acridine orange/propidium iodide (AO/PI) staining and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were used to evaluate the viability of cell and cell proliferation. Cell migration assay was analyzed using Essen BioScience IncuCyteTM Zoom system. In vivo wound healing via open excision wounds model on Sprague Dawley rat was studied within 14 days. The FT-IR spectra of GG + TiO2-NPs biofilm show main bands assigned to OH stretching, OH deformation, and TiO stretching modes. XRD pattern of GG + TiO2-NPs biofilm suggesting that ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research

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This study provides important information for the potential utilization of nanocopper in food packaging films.Graphical abstract
Source: Food Packaging and Shelf Life - Category: Food Science Source Type: research
Publication date: Available online 16 October 2019Source: Materials Science and Engineering: CAuthor(s): Rodianah Alias, Reza Mahmoodian, Krishnamurithy Genasan, Vellasamy K.M., Mohd Hamdi Abd Shukor, Tunku KamarulAbstractSurgical site infection associated with surgical instruments has always been a factor in delaying post-operative recovery of patients. The evolution in surface modification of surgical instruments can be a potential choice to overcome the nosocomial infection mainly caused by bacterial populations such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. A study was, therefore, conducte...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 19 October 2019Source: Food ChemistryAuthor(s): Tiantian Min, Zhu Zhu, Xiaoli Sun, Zhipeng Yuan, Junwei Zha, Yongqiang WenAbstractIn this work, a multifunctional food packaging composite coating with transparent, biodegradable, antifogging and antibacterial properties was designed and fabricated by quaternary ammonium salt modified chitosan (HACC) and poly (vinyl alcohol) (PVA) via a facile and environment-friendly solution casting method. A simple quaternization modification enabled the coating simultaneously to achieve excellent antifogging and antibacterial functions. The excellent ant...
Source: Food Chemistry - Category: Food Science Source Type: research
In this study, we discovered potent p53-MDM2 inhibition by 2-thiobenzyl-3-formyl quinoline, 2-thio-1,2-dihydroquinoline-3-formyl N-substituted thiosemi-carbazone and fluorine substituted new pyridine and pyran derivatives by structure-based design.Graphical abstract
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Mahmoud Amouzadeh Tabrizi, Josep Ferré-Borrull, Lluis F. MarsalAbstractFoodborne Salmonella disease is a major public health concern. Therefore, it is crucial to design a reliable biosensor to the diagnosis of this disease. Herein, we fabricated an interferometric reflectance spectroscopy (IRS) based DNA sensor for the determination of Salmonella-specific DNA fragment concentration. For this purpose, the nanoporous anodic alumina (NAA) was first fabricated. The pore walls of NAA were then functionalized with 3-amino...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 19 October 2019Source: Inorganica Chimica ActaAuthor(s): Ayman K. El-Sawaf, El Hassane AnouarAbstractThe (E)-N'-(2-hydroxybenzylidene)morpholine-4-carbothiohydrazide (H2L) ligand and its chelates with Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) have been synthesized. Analytical and spectral data prove that the ligand acts a monobasic tridentate ligand coordinated via deprotonated phenolic O, azomethine N and thione S atoms (ONS chromophore) with cobalt(II), nickel(II) and copper(II) salts leading to two fused five and six-membered chelate rings. While with zinc(II) and cadmium(II) salts the...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 18 October 2019Source: Journal of Physics and Chemistry of SolidsAuthor(s): G. Palanisamy, K. Bhuvaneswari, A. Chinnadurai, G. Bharathi, T. PazhanivelAbstractSunlight driven photocatalysis is the next step of environmental remediation, which can utilize the renewable energy to cure environmental problems. Herein we report a magnetically recoverable ZnS/Ag/CoFe2O4 nanocomposite photocatalyst for sunlight driven photocatalytic dye degradation. The composition, structure, morphology, magnetic and photophysical properties of the as prepared samples were investigated by a wide range of charact...
Source: Journal of Physics and Chemistry of Solids - Category: Physics Source Type: research
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Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, the promoter regions of 11 genes associated with contagious mastitis including CCL4, CXCL8, STAT3, IKBKB, MAPK14, NFKBIA, NFKB1, TNF, IL18, IL6, and HCK were investigated to predict the activating regulatory modules on promoters and to discover the key related transcription factors. By exploring the promoter regions, 228 genes were discovered comprising the same transcription factors modules. Out of 228 genes, 36 were validated using five microarray datasets. The promoter research of these genes revealed that as many as 7 down-regulated and 12 up-regulated genes are predictable in the network. The genes whos...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 15 October 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Yonglin Yu, Qichun Ran, Xinkun Shen, Hong Zheng, Kaiyong CaiAbstractAfter implantation into a host, titanium (Ti) orthopaedic materials are facing two major clinical challenges: bacterial infection and aseptic loosening, which directly determine the long-term survival of the implant. To endow Ti implant with self-defensive antibacterial properties and desirable osteo/angio-genic differentiation potentials, hyaluronic acid (HA)-gentamicin (Gen) conjugates (HA-Gen) and chitosan (Chi) polyelectrolyte multilayers were con...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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