A miniaturized device for biomembrane permeation analysis

In this study, we fabricated miniaturized multichannel devices (MCDs) by 3D printing, to minimize the use of skin and drug samples. The MCDs were compared with conventional static diffusion cells and achieved comparable drug permeation profiles. The finite element method-based simulation revealed the efficient carry-off of permeated ingredients by the multichannel devices, and a critical role of distance between the buffer stream and skin sample in determining the flow velocity inside the chamber. The results support these devices as qualified alternative to Franz cells for in vitro permeation studies using biomembranes, with reduced use of skins and drugs.Graphical abstract
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research