MicroRNA-140-5p: A novel circulating biomarker for early warning of late-onset post-stroke depression

Publication date: Available online 17 May 2019Source: Journal of Psychiatric ResearchAuthor(s): Huai-bin Liang, Ji-rong He, Xuan-qiang Tu, Kai-qi Ding, Guo-Yuan Yang, Yu Zhang, Li-li ZengAbstractWe aimed to explore the circulating microRNAs biomarkers in the acute stage following cerebral ischemia to earlier warn late-onset post-stroke depression (PSD). A total of 251 consecutive patients with acute ischemic stroke were recruited. They were divided into three groups depending on whether PSD had occurred at 2 weeks or 3 months since stroke: early-onset PSD, late-onset PSD, and non-depressed group. Microarray assay was conducted to identify the different expression profiles of plasma miRNAs. Comprehensive bioinformatics analysis for their integrating putative target genes was performed. The key miRNA was validated in a larger cohort and its function was further studied in ischemic mice brain. We screened three differentially expressed miRNAs in the late-onset PSD individuals, miR-140-5p and miR-221-3p were significantly upregulated while miR-1246 was downregulated. The bioinformatics analysis demonstrated that their predicted target genes were mainly enriched in axon development and Ras signaling pathway. Logistic regression analysis revealed that miR-140-5p was an independent risk factor for late-onset PSD (P = 0.017, OR = 2.313, 95%CI 1.158 to 4.617). The mir-140-5p expression on admission was significantly positively correlated with HDRS scores assessed at 3 months a...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research