Kinetics of the expression of CD163 and CD107a in the lung and tonsil of pigs after infection with PRRSV-1 strains of different virulence

This study assesses the expression, distribution and kinetics of PRRSV N-protein, CD163 and CD107a in the lung and tonsil from experimentally-infected piglets with three different PRRSV-1 strains: a virulent PRRSV-1 subtype 3 strain (SU1-bel) and two low-virulent subtype 1 strains, Lelystad virus (LV) and 215 –06. SU1-bel replicated more efficiently in the lungs and tonsils. The number of CD163+ cells decreased in both tissues from all infected groups at 7 dpi, followed by an increase at the end of the study, highlighting a negative correlation with the number of N-protein+-infected cells. A significant increase in CD107a was observed in all infected groups at 35 dpi but no differences were observed among them. Whereas the initial decrease of CD163+ cells appears to be associated to virus replication and cell death, the later recovery of the CD163+ population may be due to either the induction of CD163 in immature cells, the recruitment of CD163+ cells in the area of infection, or both. These results highlight the ability of macrophage subpopulations in infected animals to recover and restore their potential biological functions at one-month post-infection, with the greatest improvement observed in SU1-bel-infected animals.
Source: Veterinary Research Communications - Category: Veterinary Research Source Type: research

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CONCLUSIONS: SpeA and other superantigens cause dysregulated tonsil immune function, driving T cells from Tfh to a proliferating phenotype, with resultant loss of B cells and immunoglobulin production, providing superantigen-producing bacteria with a likely survival advantage. This article is protected by copyright. All rights reserved. PMID: 30815853 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
GP practices to help boost MMR uptake Related items fromOnMedica Vaccination plea as measles outbreak continues Childhood vaccine uptake slumps in England Tonsillectomy in childhood raises risk of respiratory diseases GPs put on alert for measles as cases rise
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractThe present study was conceded to evaluate the mineral concentration of lymphoid organs of broiler chicken in commonly encountered immunosuppressive diseases like an infectious bursal disease, Newcastle disease, colibacillosis, and concurrent infections of IBD-ND and IBD-coccidiosis. A total of 500 broiler chickens from each outbreak were examined, which included the diseased and dead broiler chicken. The birds examined belonged to different age groups and were assigned the group number as per age. The outbreaks which occurred in the age groups of 18, 21, 23, 25, and 27 were selected and a total of five outbreaks f...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
Publication date: Available online 22 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Andrea Müllebner, Elena L. Sassu, Andrea Ladinig, Janna Frömbling, Ingrid Miller, Monika Ehling-Schulz, Isabel Hennig-Pauka, J. Catharina DuvigneauAbstractActinobacillus pleuropneumoniae(APP) persisting in clinically healthy pigs may be the causative agent of sudden outbreaks of severe respiratory disease in swine herds. During the course of acute disease, the pathogen is eliminated from inflamed lung tissue, which is characterized by the expression of pro-inflammatory cytokines and an influx of neutrophi...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 011 Peer Reviewers: Dr Jennifer Ho, ID physician QLD, Australia and Dr Mark Little, ED physician QLD, Australia. You are working in far North Queensland and encounter a 20 year old Indigenous man with tonsillitis on your ED short stay ward round. He has been receiving IV penicillin and metronidazole overnight but is deteriorating and now cannot open his mouth beyond 1.5cm, and has a swollen neck (some might say ‘Bull neck&r...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine antitoxin bull neck c. diphtheriae c.ulcerans DAT pseudomembrane vaccine Source Type: blogs
tla A Abstract Streptococcus suis (ex Elliot 1966, Kilpper-Bälz &Schleifer 1987) is a facultatively anaerobic Gram-positive ovoid or coccal bacterium surrounded by a polysaccharide capsule. Based on the antigenic diversity of the capsule, S. suis strains are classified serologically into 35 serotypes. Streptococcus suis is a commensal of pigs, commonly colonizing their tonsils and nasal cavities, mostly in weaning piglets between 4-10 weeks of age. This species occurs also in cattle and other mammals, in birds and in humans. Some strains, mostly those belonging to serotype 2, are also pathogenic for pigs,...
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Tags: Ann Agric Environ Med Source Type: research
Authors: Gayretli Aydın ZG, Tanır G, Nar Ötgün S, Turan M, Aydın Teke T, Kaman A, Kılıç S Abstract Although a significant decrease has been reported in the incidence of diphteria in many regions of the world following the routine diphtheria immunization programs, the emergence of new cases indicated that toxigenic strains are still circulating in the community. Diphtheria vaccine does not provide protection against asymptomatic carriage and colonization of non-toxigenic Corynebacterium diphtheriae. It is a known fact that invasive infections may arise from non-toxigenic C.diphtheriae strains t...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
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Source: Journal of Medical Virology - Category: Virology Authors: Tags: Research Article Source Type: research
ConclusionsForty‐three cases, including 24 laboratory‐confirmed cases and 19 possible cases, were identified. Nurses had the highest attack rate of infection, with a rate of 36.4%. The attack rate for doctors and inpatients was 20.0% and 16.7%, respectively. HAdV55 was the sole pathogen identified during this outbreak. The hexon, fiber, and penton genes from seven isolated HAdV55 stains were sequenced. All these genes showed 100% homology and fell into the HAdV55 [P14H11F14] cluster, indicating that HAdV55 was the single viral strain for the outbreak. While not conclusive, the epidemic investigation revealed that the o...
Source: Influenza and Other Respiratory Viruses - Category: Virology Authors: Tags: Original Article Source Type: research
This study indicated that though intensive ND vaccination programs using LaSota like strains, the vNDV strains of genotype VII are still circulating in the field causing significant economic losses. The genetic variation between the used vaccine strains and the circulating NDV viruses may explain the inability of the currently used vaccines to protect chicken against vNDV genotype VII. Further studies are needed to screen the protection of the currently used vaccines against recently isolated vNDV strains
Source: Beni Suef University Journal of Basic and Applied Sciences - Category: Science Source Type: research
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