Perceptions on the adsorption of COPD biomarker vapors on violet phosphorene nanosheet - A first-principles study
Publication date: Available online 17 May 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): S. Dharani, V. Nagarajan, R. ChandiramouliAbstractWe systematically investigated the adsorption characteristics of chronic obstructive pulmonary disease (COPD) biomarker volatiles on violet phosphorene with density functional theory approach. The formation energy of violet phosphorene indicates its stable structure. The electronic properties of violet phosphorene credit that it is a suitable material for biosensors. We explored the adsorption mechanism of hexanal and nonanal molecules based on electron density variation, the density of states (DOS) spectrum, band structure analysis of violet phosphorene. The results of adsorption energy, charge transfer also strengthen that COPD volatile organic compounds can be adsorbed on violet phosphorene. The proposed report strongly values that violet phosphorene as a prominent candidate to identify the biomarkers in COPD patients from the exhaled breath.Graphical abstract
Conclusion: In subjects with COPD exacerbation, the HGS was lower than that of stable COPD patients, and this difference was not explained by age, comorbidities, severity of obstruction, or smoking. Physical inactivity and steroid use during exacerbation might be possible factors affecting HGS. HGS was moderately correlated with 6MWD in cases of exacerbation. It may be used as a measure of muscle performance in COPD exacerbation, especially when the 6-min walk test cannot be performed. PMID: 31190519 [PubMed - as supplied by publisher]
Conclusion: Challenges with using and changing inhalers has meant this market has not followed other high-volume drug classes following patent loss. This is starting to change, with the situation monitored to enhance efficient prescribing alongside continued good quality care. PMID: 31189394 [PubMed - as supplied by publisher]
Conclusions: Cigarette smoke-induced hypermethylation of the mtTFA promoter is related to the initiation and progression of COPD. Our finding may provide a new strategy for the intervention of COPD by developing demethylation agents targeting mtTFA hypermethylation. PMID: 31198067 [PubMed - as supplied by publisher]
CONCLUSION: Normocapnic hyperpnoea training may reduce the incidence of respiratory symptoms, improve pulmonary function and quality of life, and reduce depression in patients with chronic spinal cord injury, regardless of their neurological level of injury, even at more than 24 months after injury. PMID: 31198974 [PubMed - as supplied by publisher]
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Each night millions of patients use continuous positive airway pressure (CPAP) to treat obstructive sleep apnea (OSA). To facilitate monitoring of treatment success, modern CPAP machines routinely record and analyze the respiratory signal in near real-time and submit some of these data to the manufacturer's centralized cloud server. Some of the conditions frequently associated with OSA such as heart failure or chronic obstructive pulmonary disease result in characteristic changes of the respiratory signal (“signatures”), especially during exacerbations. Thus, this infrastructure could be leveraged to detect cha...
AbstractUrinary incontinence (UI) is defined as a loss of bladder control and is characterized by the complaint of any involuntary leakage of urine. Evidence suggests that the prevalence of UI is higher in subjects with chronic obstructive pulmonary disease (COPD) than in age-matched controls in both sexes. UI is classified as stress, urge, and mixed, and has a considerable impact on quality of life. However, the prevalence of UI in individuals with COPD is mostly unexplored in clinical research and often underestimated in clinical practice. Interestingly, although the involuntary leakage of a small amount of urine d...
A bullectomy is a type of surgery to remove enlarged air sacs called bullae from the lung. Learn more about the uses, procedure, and risks of a bullectomy here.
Condition: COPD Exacerbation Interventions: Device: BAN; Device: SN Sponsors: Rhode Island Hospital; Monaghan Medical Corporation Not yet recruiting
Authors: Struß N, Bauersachs J, Welte T, Hohlfeld JM Abstract Chronic obstructive pulmonary disease (COPD) primarily affects the lungs; however, cardiovascular conditions are among the most common extrapulmonary comorbidities. Besides shared risk factors such as cigarette smoking, pathophysiological connections between the lung and the heart have been identified as mediators of reduced cardiac output. Recent research has focused on hyperinflation of the lung as a pulmonary cause for heart dysfunction. Hyperinflation is a typical lung abnormality seen in COPD; it is characterized by increased residua...