Floating SERS Substrates of Silver Nanoparticles-Graphene based Nanosheets for Rapid Detection of Biomolecules and Clinical Uremic Toxins

Publication date: Available online 17 May 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Ruey-Shin Juang, Kuan-Syun Wang, Yu-Wei Cheng, Chun-Chieh Fu, Wan-Tzu Chen, Chi-Ming Liu, Chu-Chun Chien, Ru-Jong Jeng, Cheng-Cheung Chen, Ting-Yu LiuAbstractNowadays, chronic kidney disease (CKD) becomes a principal barrier in clinical diagnosis and treatment. For clinical patients, chronic kidney disease will potentially lead to multiple lesion that increase the risk of mortality. The most significant challenge in CKD is detecting uremic toxins, including small water-soluble solutes (uric acid, urea and creatinine) and protein-bound solutes (p-cresol and indoxyl sulfate). Surface-enhanced Raman scattering (SERS) platform is rapid and sensitive nanotechnology for bio-detection. Thus, the floating-typed SERS substrate is prepared by embedded silver nanoparticles (AgNPs) on the poly (diallyldimethyl-ammonium) chloride (PDDA) modified graphene oxide (GO) nanosheets for the biomolecules and uremic toxins detection. The optimal interparticle distances of AgNPs are modulated to generate the strong “hot spots” for enhancing Raman signals. The characterizations of AgNPs/GO-PDDA nanosheets are evaluated by transmission electron microscopy, zeta potential, FTIR, X-ray photoelectron spectroscopy, and Raman spectroscopy. The results show that the floating SERS-active substrate provides quantitatively linear measurement (i.e., 3.8 ×&thi...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research

Related Links:

Publication date: Available online 18 June 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Lu Dai, Abdul Rashid Qureshi, Anna Witasp, Bengt Lindholm, Peter StenvinkelAbstractChronic kidney disease (CKD) is a clinical model of premature ageing characterized by progressive vascular disease, systemic inflammation, muscle wasting and frailty. The predominant early vascular ageing (EVA) process mediated by medial vascular calcification (VC) results in a marked discrepancy between chronological and biological vascular age in CKD. Though the exact underlying mechanisms of VC and EVA are not fully elucidat...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Publication date: Available online 17 June 2019Source: American Journal of Kidney DiseasesAuthor(s): Anna Burgner, Michelle A. HladunewichWomen with chronic kidney disease (CKD) are faced with complex decisions and significant challenges during their reproductive years. Contraceptive choices have a variety of side effects that can disproportionately affect women with CKD, limiting choice. CKD itself and the therapies needed to treat severe disease can affect future fertility. When conception is desired, young women with CKD must plan meticulously because an ill-timed pregnancy can result in disease progression or flare and...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Because of the less-than-robust response to therapy and impact on choice of optimal chemotherapy and prognosis, chronic kidney disease has drawn attention in the treatment of multiple myeloma, a malignant hematologic disorder that can produce significant amounts of monoclonal immunoglobulin free light chains (FLCs). These low-molecular-weight proteins are relatively freely filtered through the glomerulus and are reabsorbed by the proximal tubule. The present study demonstrated that during the process of metabolism of immunoglobulin FLCs, ROS activated the STAT1 pathway in proximal tubule epithelium. STAT1 activation served...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionsRenal biopsies, while not commonly performed in children with SCD, were universally abnormal. Outcomes were poor in this cohort of patients despite a variety of post-biopsy interventions. Effective early intervention to prevent chronic kidney disease (CKD) is needed to reduce morbidity and mortality in children with SCD.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsPre-treatment with patiromer decreases the potassium concentration of infant formula. Calcium levels increased after treatment as expected with the majority of ion exchange occurring in 30  min. Treatment of formula with patiromer shows promise as a unique option for managing hyperkalemia.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractMembranoproliferative glomerulonephritis (MPGN) is a rare chronic kidney disease associated with complement activation. Recent immunofluorescence-based classification distinguishes between immune complex (IC)-mediated MPGN, with glomerular IgG and C3 deposits, and C3 glomerulopathies (C3G), with predominant C3 deposits. Genetic and autoimmune abnormalities causing hyperactivation of the complement alternative pathway have been found as frequently in patients with immune complex-associated MPGN (IC-MPGN) as in those with C3G. In the last decade, there have been great advances in research into the autoimmune causes o...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractBackgroundThe aims were to compare the cardiovascular disease (CVD) risk among children with chronic kidney disease (CKD) secondary to focal segmental glomerulosclerosis (FSGS) with the CVD risk of children with CKD due to other diagnoses.MethodsCasual blood pressure (BP), ambulatory blood pressure monitoring (APBM), echocardiogram, lipids, carotid intima medial thickness (cIMT), and uric acid obtained from participants in the Chronic Kidney Disease in Children (CKiD) cohort were analyzed longitudinally. Seventy-nine children with FSGS (FSGS-CKD) were compared to 196 children with non-FSGS glomerular disease (GDO-C...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Benil Hafeeq, Jyotish Chalil Gopinathan, Feroz Aziz, Sajith Narayanan, Idrees Velikkalagath, Ismail Naduvileparambil Aboobacker, NA UvaisIndian Journal of Public Health 2019 63(2):157-159 Renal replacement therapy in India is predominantly a private health-care-driven initiative making it an expensive treatment option due to high out-of-pocket expenditures. Moreover, with the rapid increase in the number of chronic kidney disease patients requiring dialysis, hemodialysis units (HDUs) are getting saturated. Community “stand-alone” dialysis centers could be an important alternative to HDUs in meeting the growing...
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
AbstractIntroductionThe kidneys contribute to maintain plasma osmolality in normal range by achieving the adequate daily osmolar urine excretion (DOUE). An equation has been described for estimating the expected daily urine volume necessary to excrete the osmolar load required to keep serum osmolality in normal range. According to this equation, a difference between real and expected daily osmolar diuresis (DOD) can be obtained, being normally this difference value zero ( ± 500 cc). However, a positive DOD difference signifies a reduced urine concentration capability, while a negative DOD difference sign...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsOur findings suggest that hypophosphatemia during the first 3  months after kidney transplantation was associated with better kidney survival.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
More News: Chemistry | Chloride | Chronic Kidney Disease | Nanotechnology | Urology & Nephrology