Methylation Signature for Prediction of Progression Free Survival in Surgically Treated Clear Cell Renal Cell Carcinoma.

CONCLUSION: The promoter methylation of ZNF278, FAM155A and DPP6 genes are associated with aggressive tumor phenotype and early development of distant metastasis in patients with surgically treated ccRCC. These potential methylation markers, either alone, or in combination, could provide novel targets for development of individualized therapeutic and prevention regimens. PMID: 31099194 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research

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Publication date: Available online 20 November 2019Source: Urology Case ReportsAuthor(s): Eric M. Chevli, Tyler J. Maiers, David J. Abramowitz, Shervin Badkhshan, John J. BodkinAbstract:Situs inversus totalis (SIT) is a rare condition with left-right mirror imaging of both abdominal and thoracic organs. While this configuration is rarely of medical importance, an understanding of this unique anatomy is essential in the setting of surgical intervention. Here we review a case of renal cell carcinoma (RCC) in the setting of SIT. The patient underwent a hand-assisted laparoscopic radical nephrectomy. Pathology revealed pT3aNxM...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Condition:   Clear Cell Renal Cell Carcinoma Intervention:   Drug: ARO-HIF2 Sponsor:   Arrowhead Pharmaceuticals Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Zhao L, Liu K, Pan X, Quan J, Zhou L, Li Z, Lin C, Xu J, Xu W, Guan X, Li H, Ni L, Gui Y, Lai Y Abstract Clear cell renal cell carcinoma (ccRCC) is a common malignancy, yet, the mechanisms underlying tumorigenesis remain unclear. Several miRNAs have been implicated in the development of RCC previously via regulation of target gene expression. As miR-625-3p has recently been identified to play a role in development of other malignancies and is reportedly upregulated in ccRCC, we sought to investigate the role of this miRNA in the progression of ccRCC. Analysis of 30 paired fresh ccRCC tissues and adjacent n...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Conclusion: CK7, CD117, and Claudin-7 are frequently expressed in CHRCC with high specificity. We recommend the routine use of these 3 markers as a routine panel when making a differential diagnosis of CHRCC and excluding other mimics. PMID: 31737127 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
ConclusionsThe evidence from this study and previous work highlights the importance of the assumptions underlying any model structure, and the need to validate assumptions regarding survival and the application of treatment effects against what is known about the characteristics of the disease.
Source: PharmacoEconomics - Category: Health Management Source Type: research
Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 38-year-old woman is evaluated during a follow-up visit for primary membranous glomerulopathy. Diagnosis was made by kidney biopsy 4 months ago, and she was found to be positive for anti–phospholipase A2 receptor (PLA2R) antibodies. Medications are furosemide, losartan, and simvastatin. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Nephrology renal cell renal cell carcinoma Source Type: blogs
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 11Author(s): A. Kawashima, M. Matsumoto, Y. Kidani, T. Yoshida, M. Matsushita, Y. Koh, K. Nakano, Y. Hayashi, Y. Ishizuya, C. Wang, T. Kato, T. Ujike, K. Fujita, M. Uemura, S. Sakaguchi, M. Nagira, N. Ohkura, H. Wada, N. Nonomura
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 11Author(s): G. Procopio, G. Apollonio, F. Cognetti, R. Miceli, M. Milella, A. Mosca, V.E. Chiuri, A. Bearz, F. Morelli, C. Ortega, F. Atzori, M. Donini, R. Ratta, A. Raimondi, M. Claps, A. Martinetti, U. Capitanio, F.G. De Braud, V. Cappelletti, E. Verzoni
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 11Author(s): L. Polanco Pujol, F. Herranz Amo, J. Caño Velasco, J. Mayor De Castro, J. Aragon Chamizo, C. Hernandez Fernandez
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 11Author(s): I. Selvi, E. Ozturk
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
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