Epigenetic Modulation on Tau Phosphorylation in Alzheimer's Disease.

Epigenetic Modulation on Tau Phosphorylation in Alzheimer's Disease. Neural Plast. 2019;2019:6856327 Authors: Yu CC, Jiang T, Yang AF, Du YJ, Wu M, Kong LH Abstract Tau hyperphosphorylation is a typical pathological change in Alzheimer's disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct changes in the DNA sequence of the gene. Epigenetic modifications, such as noncoding RNA regulation, DNA methylation, and histone modification, can directly or indirectly affect the regulation of tau phosphorylation, thereby participating in AD development and progression. This review summarizes the current research progress on the mechanisms of epigenetic modification associated with tau phosphorylation. PMID: 31093272 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research

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Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02561H, PaperXuhua Li, Jiangtao Lei, Ruxi Qi, Luogang Xie, Guanghong Wei Alzheimer disease (AD) is associated with the abnormal self-assembly of amyloid- β (Aβ) peptide into toxic oligomers and fibrils. Recent experiments reported that Aβ16-22, containing the central hydrophobic core (CHC) of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 23 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Muneeb A. Faiq, Gadi Wollstein, Joel S. Schuman, Kevin C. ChanAbstractThe cholinergic system has a crucial role to play in visual function. Although cholinergic drugs have been a focus of attention as glaucoma medications for reducing eye pressure, little is known about the potential modality for neuronal survival and/or enhancement in visual impairments. Citicoline, a naturally occurring compound and FDA approved dietary supplement, is a nootropic agent that is recently demonstrated to be effective in ameliorating ischemi...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Those portions of the modern longevity community interested in bringing an end to aging and extending healthy human life span indefinitely tend to be the older portions, people who have been a part of the broader movement for quite some time. Newcomers tend to be more moderate, aiming at lesser goals. Perhaps this is a result of the successful projects, such as the SENS Research Foundation and Methuselah Foundation, tending to moderate their rhetoric as they attract a broader and larger base of support. I think that this road to moderation might be a problem, and that there is thus a continued role for those who loudly dec...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Publication date: Available online 22 June 2019Source: NeuroImageAuthor(s): Martin Sjøgård, Xavier De Tiège, Alison Mary, Philippe Peigneux, Serge Goldman, Guy Nagels, Jeroen van Schependom, Andrew J. Quinn, Mark Woolrich, Vincent WensAbstractThe default-mode network (DMN) and its principal core hubs in the posterior midline cortices (PMC), i.e., the precuneus and the posterior cingulate cortex, play a critical role in the human brain structural and functional architecture. Because of their centrality, they are affected by a wide spectrum of brain disorders, e.g., Alzheimer's disease. Non-invasive elect...
Source: NeuroImage - Category: Neuroscience Source Type: research
Researchers from Daegu Gyeongbuk Institute of Science and Technology (DGIST) in South Korea have developed a new microrobot that can precisely deliver therapeutic cells to very specific parts of the brain. Their work, recently published in Science Ro...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine Nanomedicine Neurology Neurosurgery Source Type: blogs
(Society of Nuclear Medicine and Molecular Imaging) The strongest genetic risk factor for Alzheimer's disease is the apolipoprotein E type 4 allele (ApoEε4). Research presented by Manish Paranjpe at the 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) used positron emission tomography (PET) to show that women who are ApoEε4 carriers and already experiencing mild cognitive impairment are more susceptible than men to tau accumulation in the brain.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Boston University School of Medicine) A new study raises the possibility that close-range blast exposure among veterans with a genetically higher risk for Alzheimer's disease (AD), may make them more susceptible to degradation of their white matter, the part of the brain made of fiber connections called axons that connect nerve cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusion: Textures of the hippocampus, precuneus and posterior cingulate cortex predicted conversion from MCI to Alzheimer disease at an earlier time point and with higher accuracy than hippocampal volume. PMID: 31228173 [PubMed - as supplied by publisher]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research
Authors: Leng Y, Redline S, Stone KL, Ancoli-Israel S, Yaffe K Abstract INTRODUCTION: Little is known about the longitudinal association between napping and cognitive impairment in older adults. METHODS: We used wrist actigraphy to measure naps in 2751 community-dwelling older men. Cognition was assessed repeatedly over 12 years, and clinically significant cognitive impairment was determined by physician diagnosis, Alzheimer's medication use or a significant cognitive decline. RESULTS: After adjustment for all covariates, men with longer napping duration had greater cognitive decline and higher risk of...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This corss-sectional diagnostic study evaluates the accuracy of fully automated plasma assays in measuring plasma β-amyloid and tau in patients with and without cognitive impairment in the Swedish BioFINDER study and an independent validation cohort.
Source: JAMA Neurology - Category: Neurology Source Type: research
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