The Burden of Hepatitis E among Patients with Hematological Malignancies: a Retrospective European Cohort Study
The hepatitis E virus (HEV), the causative agent of hepatitis E, is a member of the Hepeviridae family that includes enterically-transmitted, small, non-enveloped positive-sense RNA viruses that can infect mammals (Orthohepevirus A, C and D), birds (Orthohepevirus B) and trout (Piscihepevirus). There are four major HEV genotypes (HEV-1 to HEV-4) that can infect humans. HEV is predominately transmitted with contaminated water in low-income countries (mostly HEV-1 and HEV-2) and with contaminated meat and offal that originate from HEV-infected animals (HEV-3 and HEV-4) in high-income countries.
This study applies a new measurement approach and assesses clinic-level factors associated with preventive care delivery.MethodsThis retrospective longitudinal cohort study of 94 community health centers used electronic health record data from the OCHIN community health information network, 2014–2015. Clinic-level preventive ratios (time covered by a preventive service/time eligible for a preventive service) were calculated in 2017 for 12 preventive services with A or B recommendations from the U.S. Preventive Services Task Force along with an aggregate preventive index for all services combined. For each service, mu...
AbstractPurpose of reviewHepatitis C virus (HCV) infection is a principal cause of morbidity, mortality, and economic burden, and the global elimination of HCV is now considered a public health objective. Globally, an estimated 71 million have chronic HCV infection with an estimated annual mortality of 3,99,000.Recent findingsThe 69th World health Assembly has endorsed the global HCV elimination strategy by 2030, which is made possible because of all oral, cost-effective, efficacious, generic direct-acting antivirals. The public health strategy targets not only diagnosed chronic hepatitis C patients but also asymptomatic u...
In this study, we designed a fluorescence enhancement strategy based on silver nanoparticle (AgNP) aggregates for the detection of hepatitis B virus DNA sequences. AgNPs were functioned with recognition probes (Cy3-probe) and hybrid probes (Oligomer-A and Oligomer-B). The presence of target DNA mediated the formation of sandwich complexes between the immobilized capture probes and the functionalized AgNPs, which was followed by hybridization-induced formation of AgNP aggregates. The fluorescent intensity could be extremely amplified by both the increasing number of fluorophores and metal enhanced fluorescence (MEF) effect....
Conclusions: The prevalence of HBV in SOM patients undergoing CMT in our study was similar to the estimated prevalence in general Thai population, but the screening rate was quite low. Cases of HBVr causing significant hepatitis occurred in the unscreened group; therefore, HBV screening and treatment in SOM patients should be considered in HBV-endemic areas. PMID: 31309773 [PubMed - as supplied by publisher]
Conditions: Hepatitis B; HBV; Hepatitis B, Chronic Interventions: Drug: Inarigivir soproxil; Drug: Nucleoside/nucleotide (NUC) analogue inhibitors Sponsors: Spring Bank Pharmaceuticals, Inc.; PRA Health Sciences Recruiting
Condition: HIV-1-infection Interventions: Drug: dolutegravir; Drug: atazanavir boosted with ritonavir; Drug: tenofovir + lamivudine +efavirenz; Drug: Lamivudine Sponsors: French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS); Mylan Laboratories Not yet recruiting
[Observer] Prominent biomedical scientist and social activist, Dr. Dougbeh Christopher Nyan, has said that, "a major outbreak of Cholera and Hepatitis A infection may be looming over Liberia, if the government does not urgently address the proper disposal of mountains of garbage and solid wastes that has accumulated and sits in and around the Capital, Monrovia and its environs."
ConclusionsProlonged use of cyclosporine may expose to several dose-related adverse events and may contribute to the development of allograft dysfunction but it does not necessarily cause relentless, progressive transplant failure if patients are carefully and consistently monitored during the follow-up.
Conclusions: This study concludes that elevated ALT levels are seen in patients on antiretroviral therapy and persist throughout the course of first year, though maximum levels are seen at around twenty four weeks of therapy. Total hepatotoxicity was found to be 16.89%. Longer follow up of patients is required to assess the effect of ALT elevations on morbidity and mortality of patients and a close monitoring of ALT is required in patients on ART and other hepatotoxic therapies. PMID: 31304710 [PubMed - in process]
Authors: Deshwal R, Arora S Abstract Objectives: The main aim of this study was to assess vitamin D [25(OH)D]levels in an HIV infected adult population and to define HIV and antiretroviral-related factors associated with vitamin D deficiency. Methods: This observational analytical study was conducted on 475 adult patients on follow up at Apex Immunodeficiency Center of Base Hospital, Delhi Cantt. We estimated the prevalence of vitamin D insufficiency/deficiency(