Lipitor (atorvastatin) vs. Niacin (nicotinic acid, vitamin B3)
Title: Lipitor (atorvastatin) vs. Niacin (nicotinic acid, vitamin B3)Category: MedicationsCreated: 5/17/2019 12:00:00 AMLast Editorial Review: 5/17/2019 12:00:00 AM
COVID, sacubitril/valsartan, left atrial appendage occlusion, and statins are the topics Dr John Mandrola discusses in this week ’ s podcast.theheart.org on Medscape
AbstractRosuvastatin/ezetimibe combines two lipid-lowering agents: rosuvastatin, an HMG-CoA reductase inhibitor (i.e. statin) with particularly strong inhibitory effects on hepatic cholesterol synthesis, and ezetimibe, which inhibits the intestinal absorption of cholesterol. A fixed-dose combination (FDC) of rosuvastatin/ezetimibe is indicated as an adjunctive therapy to diet for the management of primary hypercholesterolemia in adults in numerous countries worldwide. In well-designed clinical trials evaluating the therapeutic efficacy of rosuvastatin/ezetimibe administered as either separate agents or as an FDC, rosuvasta...
AbstractIntroductionProprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are proven to have profound lowering of low-density lipoprotein cholesterol (LDL-C) in patients with clinical atherosclerotic cardiovascular disease or familial hypercholesterolemia.AimThe primary purpose of this study was to evaluate PCSK9i utilization in older adults, with a focus on efficacy outcomes within 6 months of initiation. Secondary outcomes included tolerability, out-of-pocket expenses (OPE), and barriers to initiation of therapy.MethodsWe conducted a retrospective chart review of patients ≥ 65 years prescribed P...
Publication date: Available online 8 July 2020Source: Pharmacology &TherapeuticsAuthor(s): Ole Köhler-Forsberg, Christian Otte, Stefan M. Gold, Søren Dinesen Østergaard
With trial data for this age group in short supply, a US veterans cohort study saw a 25% drop in all-cause mortality for those newly starting on a statin at age 75 or older.Medscape Medical News
CONCLUSIONS: Simvastatin inhibits proliferation and promotes apoptosis of NPC cells by inhibiting the NF-κB pathway. PMID: 32633363 [PubMed - in process]
CONCLUSIONS: drug scheduling by nurses requires a review of the criteria for proposing schedules for drugs in order to ensure patient safety. PMID: 32638928 [PubMed - in process]
People 75 and older who were free of heart disease and prescribed a statin wound up with a 25% lower risk of death from any cause and a 20% lower risk of heart-related death, researchers reported July 7 in the Journal of the American Medical Association.
Conclusion: The level of adherence to the recommendations of U.S. and Brazilian guidelines of dyslipidemia for statin use was low. Most patients used a moderate intensity statin, despite having a high cardiovascular risk. Simvastatin was the most prescribed statin. PMID: 32634034 [PubMed - as supplied by publisher]
AbstractPurpose of ReviewThe purpose of this review is to discuss the updated guideline recommendations on management of dyslipidemia for prevention and treatment of cardiovascular disease.Recent FindingsThe American College of Cardiology/American Heart Association (ACC/AHA) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) published revised cholesterol management guidelines in 2018 and 2019, respectively, to reflect new evidence in the field. Broadly speaking, both emphasize refining cardiovascular disease risk estimation and aggressively lowering low-density lipoprotein-cholesterol (LDL-C) wit...