Lipitor (atorvastatin) vs. Zetia (ezetimibe)

Title: Lipitor (atorvastatin) vs. Zetia (ezetimibe)Category: MedicationsCreated: 5/17/2019 12:00:00 AMLast Editorial Review: 5/17/2019 12:00:00 AM
Source: MedicineNet Cholesterol General - Category: Cardiology Source Type: news

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STATINS can cause a number of side effects in some people, like many medications do. Nonetheless, some are more uncommon than others and can be troublesome. There are some signs to look out for which should be immediately checked with a doctor.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Dual antiplatelet therapy after PCI, statin side effects, nightshift work and AF, and a cautionary note regarding therapeutic enthusiasm in HF care are the topics John Mandrola, MD, discusses in this week ’s on Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology Commentary Source Type: news
Expert Opin Investig Drugs. 2021 Sep 24. doi: 10.1080/13543784.2021.1985463. Online ahead of print.ABSTRACTINTRODUCTION: Recent years have witnessed unprecedented progress in stroke care, but unmet needs persist regarding the efficacy of acute treatment and secondary prevention. Novel approaches are being tested to enhance the efficacy of thrombolysis or provide neuroprotection in non-thrombolized patients.AREAS COVERED: The current review highlights pharmaceutical agents under evaluation in clinical trials concerning the acute, subacute, and chronic phase post-stroke. We examine the evidence in favor of tenecteplase as an...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Authors: Source Type: research
Curr Med Res Opin. 2021 Sep 24:1. doi: 10.1080/03007995.2021.1984222. Online ahead of print.ABSTRACTOBJECTIVE: To investigate whether statin adherence (defined as proportion days covered, PDC) is associated with LDL-c response in statin initiators on standard and low starting-dose of statins, and to detect a possible interaction with sex.METHODS: An inception cohort study was conducted using the PharmLines Initiative, a linkage between the Lifelines Cohort Study and University of Groningen's (prescription database). First-time statin users were followed from baseline to follow-up measurement. We matched participants...
Source: Current Medical Research and Opinion - Category: Research Authors: Source Type: research
A new study sheds light on the question of whether statin therapy negatively impacts memory and cognition.Journal of the American College of Cardiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Nasal delivery has been indicated as one of the most interesting alternative routes for the brain delivery of neuroprotective drugs. Nanocarriers have emerged as a promising strategy for the delivery of neurotherapeutics across the nasal epithelia. In this work, hybrid lecithin/chitosan nanoparticles (LCNs) were proposed as a drug delivery platform for the nasal administration of simvastatin (SVT) for the treatment of neuroinflammatory diseases. The impact of SVT nanoencapsulation on its transport across the nasal epithelium was investigated, as well as the efficacy of SVT-LCNs in suppressing cytokines release in a cellula...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Acta Pharmacol Sin. 2021 Sep 22. doi: 10.1038/s41401-021-00769-3. Online ahead of print.ABSTRACTDespite improvements in cardiovascular disease (CVD) outcomes by cholesterol-lowering statin therapy, the high rate of CVD is still a great concern worldwide. Dehydrocorydaline (DHC) is an alkaloidal compound isolated from the traditional Chinese herb Corydalis yanhusuo. Emerging evidence shows that DHC has anti-inflammatory and antithrombotic benefits, but whether DHC exerts any antiatherosclerotic effects remains unclear. Our study revealed that intraperitoneal (i.p.) injection of DHC in apolipoprotein E-deficient (ApoE-/-) mi...
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
Ann Thorac Surg. 2021 Sep 21:S0003-4975(21)01584-8. doi: 10.1016/j.athoracsur.2021.08.024. Online ahead of print.ABSTRACTBACKGROUND: The current study sought to investigate the association between statin intensity and long-term clinical outcomes according to initial clinical presentation following CABG.METHODS: A total of 6,531 patients who underwent CABG were finally included in this study, and the study population was classified into four groups according to statin intensity (no or low[atorvastatin
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Diabetes Metab. 2021 Sep 19:101284. doi: 10.1016/j.diabet.2021.101284. Online ahead of print.ABSTRACTAIM: Dyslipidaemia in type 2 diabetes mellitus (T2DM), which increases cardiovascular risk, includes abnormal metabolism of low-density lipoproteins (LDL). Our group has recently shown that liraglutide increases LDL catabolism in patients with T2DM and that it reduces the expression of PCSK9 (a major inhibitor of LDL-receptor expression) in vitro and in mice. This prompted us to study the effect of liraglutide on plasma PCSK9 level in patients with T2DM.METHODS: We studied prospectively 82 patients with T2DM (51 without sta...
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Source Type: research
AbstractDespite the availability of lipid-lowering therapies (LLTs) that are safe and effective, the overall rate of low-density lipoprotein cholesterol (LDL-C) control at a population level in real-life studies is low. Higher-intensity treatment, earlier intervention, and longer-term treatment have all been shown to improve outcomes. However, in clinical practice, actual exposure to LLT is a product of the duration and intensity of, and adherence to, the treatment. To increase exposure to LLTs, the European Society of Cardiology guidelines recommended a stepwise optimization of LLTs by increasing statin intensity to the m...
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
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