Benefits of beta blockers in patients with heart failure and reduced ejection fraction: network meta-analysis

Source: BMJ Area: News Beta blockers have been shown in randomised trials to prolong survival, prevent arrhythmia, improve symptoms of heart failure and left ventricular ejection fraction, and control ventricular rate, especially in patients with chronic heart failure. However, controversy exists as to the optimal selection of a particular agent for management of heart failure, as they differ in their selectivity for adrenergic receptors and their effects on the peripheral circulation.   This systematic review and network meta-analysis was conducted of efficacy of different beta- blockers in heart failure to clarify whether any particular agent is superior or whether the benefits of these agents are mainly due to a class effect.   A literature search was conducted for randomised trials comparing beta-blockers with other beta-blockers or other treatments, and 21 were included, focusing on atenolol, bisoprolol, bucindolol, carvedilol, metoprolol, and nebivolol. The primary endpoint was ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news

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Left ventricular noncompaction cardiomyopathy is a heart disease with relevant potential complications including heart failure, life-threatening arrhythmias, and embolic events. In order to prevent adverse outcomes, it is crucial to appropriately recognize and manage this cardiomyopathy. In this paper, we report the main clinical presentations and imaging modalities used for diagnosis, including echocardiography and magnetic resonance imaging. We highlight the role of a comprehensive functional cardiac evaluation and the possible prognostic implications of both systolic and diastolic dysfunction. Furthermore, we summarize ...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Omecamtiv mecarbil (OM) is a first in class selective myosin activator, developed to increase contractile force without altering intracellular calcium concentrations in patients with advanced heart failure (AHF). We sought to investigate the effect of OM on contractility, arrhythmia genesis and interaction with Beta 1-adrenoceptor (B1AR) inotropes directly on explanted human failing heart.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (895) Source Type: research
Amiodarone is a commonly used anti-arrhythmic medication for atrial and ventricular arrhythmias in end-stage heart failure. Due to heavy iodine content, amiodarone is implicated in a variety of thyroid disorders, which could lead to adverse outcomes in cardiac transplant (CT) patients. Data on the development of post-CT lymphocytic thyroiditis (LT) in patients with pre-CT amiodarone use is limited. We aimed to study the development of amiodarone-induced LT in CT patients in a tertiary care transplant center in the United States.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (394) Source Type: research
We describe the anesthetic management for this innovative technique addressing technique-specific issues such as arrhythmia management, hemostasis, right heart failure and postoperative pain control.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (852) Source Type: research
Int J Angiol DOI: 10.1055/s-0040-1705111Atrial fibrillation is a common arrhythmia which may cause symptoms that significantly impact quality of life and is associated with increased risk of stroke, heart failure, and sudden death. Over the past three decades many surgical techniques as well as catheter-bases procedures have been developed to treat atrial fibrillation. In this review we describe the indications, treatments, outcomes, surgical techniques, and technical advances reported in the literature. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of conten...
Source: International Journal of Angiology - Category: Cardiology Authors: Tags: Invited Papers Source Type: research
CONCLUSION: MiR-144 regulates proliferation and apoptosis of HG-induced AC16 cardiomyocytes through targeting the CTRP3/JNK signaling pathway, providing a novel avenue for treatment of DCM. PMID: 32211094 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
In this study, we report a novel approach for measurement of interstitial cardiac norepinephrine, using minimally invasive electrode-based fast scanning cyclic voltammetry (FSCV) applied in a beating porcine heart. The first multi-spatial- and high temporal- resolution, multi-channel measurements of norepinephrine (NE) release in vivo are provided. Our data demonstrate rapid changes in interstitial NE profiles with regional differences in response to coronary ischemia, sympathetic nerve stimulation, and alterations in preload/afterload. PMID: 32216617 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
idi E Abstract Obstructive sleep apnoea syndrome is a growing health concern, affecting nearly one billion people worldwide; it is an independent cardiovascular risk factor, associated with incident obesity, insulin resistance, hypertension, arrhythmias, stroke, coronary artery disease and heart failure. Obstructive sleep apnoea-related cardiovascular and metabolic co-morbidities are a major concern for prognosis and the complexity of obstructive sleep apnoea integrated care. Continuous positive airway pressure, the first-line therapy for the treatment of obstructive sleep apnoea, is highly effective at improving ...
Source: Archives of Cardiovascular Diseases - Category: Cardiology Authors: Tags: Arch Cardiovasc Dis Source Type: research
Rapid firing from pulmonary veins (PVs) frequently initiates atrial fibrillation, which is a common comorbidity associated with hypertension, heart failure, and valvular disease, i.e., conditions that pathologically increase cardiomyocyte stretch. Autonomic tone plays a crucial role in PV arrhythmogenesis, while its interplay with myocardium stretch remains uncertain. Two-microelectrode technique was used to characterize electrophysiological response of Wistar rat PV to adrenaline at baseline and under mild (150 mg of applied weight that corresponds to a pulmonary venous pressure of 1 mmHg) and moderate (10 g, ∼26 mmHg...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionAdjusting for imbalances in baseline variables that influence outcomes (or the response to therapy or both) can improve the power around the estimate of the effect of treatment and may alter its statistical significance. Along with the CHARM-Preserved results, these findings suggest that angiotensin-receptor blockers may have a modest effect in HFpEF.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
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