Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study.

CONCLUSIONS: Noncardiac surgery was associated with an increase in atherogenic leukocyte subsets. In a post hoc analysis, elevated pre-OP presepsin was associated with MACCE and improved NT-proBNP-based risk assessment. After validation in an independent data set, a presepsin cutoff of 184 pg·mL might qualify to complement NT-proBNP-based risk prediction, thereby increasing the proportion of correctly identified high-risk patients.
PMID: 31094810 [PubMed - in process]

Source: Anesthesia and Analgesia - May 18, 2019 Category: Anesthesiology Authors: Handke J, Scholz AS, Gillmann HJ, Janssen H, Dehne S, Arens C, Kummer L, Uhle F, Weigand MA, Motsch J, Larmann J Tags: Anesth Analg Source Type: research