Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation.

CONCLUSIONS: Probucol corrected deflection of genotype distribution in propagation of the LCAT-deficient mice but not the ABCA1-deficient mice at the weaning stage, apparently not through normalization of hypoalphalipoproteinemia. PMID: 31092744 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

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Publication date: Available online 19 October 2019Source: Biological ControlAuthor(s): Qiya Yang, Junwei Diao, Dhanasekaran Solairaj, Ngolong Ngea Guillaume Legrand, Hongyin ZhangAbstractThe present study investigated the effect of ascorbic acid (Vitamin C, VC) at 250μg/mL in the enhancement of biocontrol efficacy of Pichia caribbica against blue mold decay caused by Penicillium expansum on apples. Compared to the performance of the yeast without treatment, P. caribbica induced by 250 μg/mL of VC potentially enhanced biocontrol activity against P. expansum and high growth rate on the apple surface when stored at 20&d...
Source: Biological Control - Category: Biology Source Type: research
CONCLUSIONSĖ NOACs reduced all-cause mortality in patients with or at risk for CAD or PAD, even though they increased the risk of major bleeding. Future studies regarding the best doses of NOACs are warranted. PMID: 31625706 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Publication date: Available online 19 October 2019Source: Comparative Biochemistry and Physiology Part C: Toxicology &PharmacologyAuthor(s): Shouta M.M. Nakayama, Ayuko Morita, Yoshinori Ikenaka, Yusuke K. Kawai, Kensuke P. Watanabe, Chihiro Ishii, Hazuki Mizukawa, Yared B. Yohannes, Keisuke Saito, Yukiko Watanabe, Masaki Ito, Natsuo Ohsawa, Mayumi IshizukaAbstractWorldwide use of anticoagulant rodenticides (ARs) for rodents control has frequently led to secondary poisoning of non-target animals, especially raptors. In order to suggest some factors that may help considering the mechanism of the incidents, this study fo...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - Category: Toxicology Source Type: research
The vitamin is frequently linked to healthy cognitive aging and adequate levels may help to reduce dementia risk. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Memory subscribers-only Source Type: blogs
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showe...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsDifferential disease classification among men who may be recommended to undergo and then consider whether to accept a prostate biopsy leads to inaccurate identification of prostate cancer risk factors. Imputing a man’s prostate cancer status reduces detection bias. Covariate adjustment does not address the problem of outcome misclassification. Cohorts evaluating incident prostate cancer should collect longitudinal screening and biopsy data to adjust for this potential bias.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Authors: Buccheri S, Capodanno D, James S, Angiolillo DJ Abstract Introduction: Potent platelet inhibition reduces the risk of thrombotic complications including myocardial infarction and death in patients with acute coronary syndrome (ACS). Targeting different pathways involved in thrombotic processes have synergistic effects and more effectively counteract thrombosis both in the acute and long-term following an ACS. Unavoidably, more potent platelet inhibition increases the risk of bleeding. In light of the adverse prognostic implications associated with bleeding, including increased mortality, safety aspects wit...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Authors: Iqbal Z, Dhage S, Mohamad JB, Abdel-Razik A, Donn R, Malik R, Ho JH, Liu Y, Adam S, Isa B, Stefanutti C, Soran H Abstract Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel drugs that have been developed since the discovery of the PCSK9 protein in 2003. In addition to background statin treatment they reduce low density lipoprotein cholesterol (LDL-C) to unprecedented levels and have shown encouraging results in improving cardiovascular events. Concerns regarding the safety of PCSK9 inhibitors and very low LDL-C have somewhat been allayed after several longer-term prosp...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Publication date: Available online 18 October 2019Source: Meta GeneAuthor(s): Mai Shaker, Taghreed Shalabi, Khaled R. Gaber, Khalda AmrAbstractBackgroundLeptin is an important hormone during implantation processes and plays a pivotal role in regulating the development of placenta and endo-metrial receptivity. miRNAs are associated with endometrial diseases, preeclampsia, neural tube defects and infertility, providing their potential role in the function of normal reproductive system. The aim of this study was to investigate the role of miRNA-27a and leptin polymorphisms in the development of idiopathic recurrent pregnancy ...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Authors: Campos J, Brill A Abstract Deep vein thrombosis (DVT) is a disease with high prevalence and morbidity. It can lead to pulmonary embolism with severe respiratory insufficiency and risk of death. Mechanisms behind all stages of DVT, such as thrombosis commencement, propagation, and resolution, remain incompletely understood. Animal models represent an invaluable tool to explore these problems and identify new targets for DVT prevention and treatment. In this review, we discuss existing models of venous thrombosis, their advantages and disadvantages, and applicability to studying different aspects of DVT path...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
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