The Relationship between Serum Alkaline Phosphatase and Arterial Stiffness in Korean Adults.

CONCLUSIONS: Serum ALP level was positively and independently associated with baPWV in men and women, suggesting that an elevated ALP level may be a useful surrogate marker for arterial stiffness in adult men and women. PMID: 31092766 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

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Authors: Pereira PG, Rabelo K, da Silva JFR, Ciambarella BT, Argento JGC, Nascimento ALR, Vieira AB, de Carvalho JJ Abstract Hypertension is characterized by persistent elevated blood pressure levels, one of the leading causes of death in the world. Renovascular hypertension represents the most common cause of secondary hypertension, and its progress is associated with overactivation of the renin angiotensin aldosterone system (RAAS), causing systemic and local changes. Aliskiren is a renin-inhibiting drug that optimizes RAAS suppression. In this sense, the objective of the present study was to analyze the morphoph...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Publication date: Available online 18 October 2019Source: Inorganica Chimica ActaAuthor(s): Elizabeth L.S. Cheu, Donald T.T. Yapp, Lynsey Huxham, Brian O. Patrick, Brian R. JamesAbstractReported are the syntheses of ten, new disulfoxides, and four known ones, of the type R-S(O)-CH2)n-(O)S-R (n = 2 or 3, R = alkyl) that were formed by oxidizing the corresponding dithioethers, RS(CH2)nSR, using acid solutions of DMSO or H2O2 as oxidants. The disulfoxides were then reacted with either commercial RuCl3┘áH2O, K3(RuCl6), or the so-called Ru ‘Blue’ or ‘Red’ solutions, in aqueous or alcohol (MeOH, EtOH) sol...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Authors: Buccheri S, Capodanno D, James S, Angiolillo DJ Abstract Introduction: Potent platelet inhibition reduces the risk of thrombotic complications including myocardial infarction and death in patients with acute coronary syndrome (ACS). Targeting different pathways involved in thrombotic processes have synergistic effects and more effectively counteract thrombosis both in the acute and long-term following an ACS. Unavoidably, more potent platelet inhibition increases the risk of bleeding. In light of the adverse prognostic implications associated with bleeding, including increased mortality, safety aspects wit...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Authors: Iqbal Z, Dhage S, Mohamad JB, Abdel-Razik A, Donn R, Malik R, Ho JH, Liu Y, Adam S, Isa B, Stefanutti C, Soran H Abstract Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel drugs that have been developed since the discovery of the PCSK9 protein in 2003. In addition to background statin treatment they reduce low density lipoprotein cholesterol (LDL-C) to unprecedented levels and have shown encouraging results in improving cardiovascular events. Concerns regarding the safety of PCSK9 inhibitors and very low LDL-C have somewhat been allayed after several longer-term prosp...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Publication date: Available online 18 October 2019Source: European UrologyAuthor(s): Christopher R. Chapple, Francisco Cruz, Linda Cardozo, David Staskin, Sender Herschorn, Nurul Choudhury, Matthias Stoelzel, John Heesakkers, Emad SiddiquiAbstractBackgroundMirabegron, a β3-adrenoreceptor agonist, is an alternative drug to antimuscarinics for overactive bladder (OAB) symptoms.ObjectiveTo summarise safety and efficacy reporting of mirabegron treatment for OAB symptoms.Design, setting, and participantsPooled data analysed from 10 phase 2–4, double-blind, 12-wk mirabegron monotherapy studies in adults with OAB who h...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conclusion: Overall developed nanofibers presented themselves to be potential drug delivery candidates for drugs having poor water solubility. PMID: 31625774 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Authors: Campos J, Brill A Abstract Deep vein thrombosis (DVT) is a disease with high prevalence and morbidity. It can lead to pulmonary embolism with severe respiratory insufficiency and risk of death. Mechanisms behind all stages of DVT, such as thrombosis commencement, propagation, and resolution, remain incompletely understood. Animal models represent an invaluable tool to explore these problems and identify new targets for DVT prevention and treatment. In this review, we discuss existing models of venous thrombosis, their advantages and disadvantages, and applicability to studying different aspects of DVT path...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
ConclusionsThese findings confirm a relationship between alexithymia and essential arterial hypertension, but they also highlight that alexithymia appears to be associated with higher severity of hypertension. Alexithymia could be a facet of uncontrolled hypertension.
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 18 October 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Lorraine Carroll, Louise Gallagher, Valerie SmithAbstractMaternal perception of reduced fetal movements (RFM) is an important clinical marker to identify women at higher risk of adverse perinatal outcomes. Preventing and reducing stillbirths can only be achieved through better detection and management of women with RFM, however the characteristics of women who present with RFM in pregnancy vary. A systematic review was conducted to explore the risk factors associated with reduced fetal...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 18 October 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Anita Morandi, Massimiliano Corradi, Claudia Piona, Elena Fornari, Rossella Puleo, Claudio MaffeisAbstractBackground And Aimsoxidative stress leading to endothelial dysfunction is a candidate driver of obesity-related hypertension. We aimed to assess whether the total anti-oxidant capacity (TAC) was associated with blood pressure in children/adolescents with obesity.Methods And Resultsone hundred and fifty-two children/adolescents with obesity (79 boys; age 11.9+/-2.5 years) underwent blood drawing for the ...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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