Stereotactic Radiosurgery for Low-Grade Gliomas.

Stereotactic Radiosurgery for Low-Grade Gliomas. Prog Neurol Surg. 2019 May 16;34:184-190 Authors: Niranjan A, Faramand A, Lunsford LD Abstract Low-grade gliomas represent a heterogeneous group of tumors. The goals of treatment include prolonged survival and reduced morbidity. Treatment strategies vary depending upon tumor histology, anatomic location, age, and the general medical condition of the patient. Safe surgical resection remains the first choice for the treatment of resectable tumors. In cases of unresectable lesions, adjuvant radiotherapy and chemotherapy are considered. Several reports in recent years have documented the safety and effectiveness of stereotactic radiosurgery (SRS) in controlling tumor growth and improving patients' survival for patients with low-grade gliomas. Patients with progressive, pilocytic, or grade 2 fibrillary astrocytomas, located in critical or deep areas of the brain, are ideal candidates for radiosurgery. The use of SRS as part of multimodal therapy for progressive, recurrent, or unresectable pilocytic or WHO grade 2 fibrillary astrocytomas is a safe and promising therapeutic modality. Gamma Knife radiosurgery has progressively gained more relevance in the management of low-grade gliomas. PMID: 31096253 [PubMed - as supplied by publisher]
Source: Progress in Neurological Surgery - Category: Neurosurgery Tags: Prog Neurol Surg Source Type: research

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Michal Yalon1†, Amos Toren1,2†, Dina Jabarin2, Edna Fadida3, Shlomi Constantini3 and Ruty Mehrian-Shai1* 1Pediatric Hemato-Oncology, Edmond and Lilly Safra Children's Hospital and Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel 2The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel 3Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv-Sourasky Medical Center, Tel Aviv, Israel Pediatric brain tumors are the most common solid tumor type and the leading cause of cancer-related death in children. The immune system plays an important r...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: The efficacy of brainstem gliomas—treated with CyberKnife is efficacious with mild toxicity. Introduction Brainstem gliomas (BSGs) account for 5–15% of brain tumors and more likely happen in children (1). BSGs constitute at least 20% of childhood brain neoplasms (2), and the peak age is 7–9 years. In contrast, BSGs is rare in the adult population and account for only 1.5–2.5% of brain glioma, with a peak age of 40–70 years (1). Diffuse intrinsic pontine glioma(DIPG) was the most common type of BSG is that could invade the whole brainstem including midbrain, pons as well as me...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, we have shown the safety and efficacy of Vemurafenib in a pediatric patient with DS affected by PXA. Ethics Statement This study was carried out in accordance with the recommendations of the Internal Review Board of the Bambino Gesù Children's Hospital with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Internal Review Board of the Bambino Gesù Children's Hospital. Informed Consent The authors declare that written informed consent was obtained from the pat...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionTrametinib appears to be a suitable option for refractory pediatric low-grade glioma and warrants further investigations in case of progression.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Authors: Burger MC, Ronellenfitsch MW, Lorenz NI, Wagner M, Voss M, Capper D, Tzaridis T, Herrlinger U, Steinbach JP, Stoffels G, Langen KJ, Brandts C, Senft C, Harter PN, Bähr O Abstract BRAF V600E mutations occur frequently in malignant melanoma, but are rare in most malignant glioma subtypes. Besides, more benign brain tumors such as ganglioglioma, dysembryoblastic neuroepithelial tumours and supratentorial pilocytic astrocytomas, only pleomorphic xanthoastrocytomas (50-78%) and epitheloid glioblastoma (50%) regularly exhibit BRAF mutations. In the present study, we report on three patients with recurrent m...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
AbstractA 5-year-old boy underwent biopsy of an intra-axial calcified tumor in the hypothalamus, which was incidentally found. Based on the presence of ganglion-like cells combined with glial cell element, the pathological diagnosis was ganglioglioma. Because the tumor grew gradually in size over the next 2  years, he underwent chemotherapy with temozolomide. However, at 8 years of age, the boy developed hydrocephalus and the cystic lesion had re-grown. Endoscopic cyst fenestration and tumor biopsy was performed, and pathological diagnosis was tentatively oligodendroglioma based on the presence of tu mor cells wi...
Source: Brain Tumor Pathology - Category: Neurology Source Type: research
Conclusion: Compared to PFT patients treated with surgery alone, PFT patients treated with chemo-radiotherapy showed lower hippocampal volumes and altered hippocampal growth trajectory. Serial quantitative MRI measures of brain may provide a neuroanatomical substrate for assessing functional impact on normal brain function following treatment of posterior fossa tumours. PMID: 28748803 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
This article also comprises a review of the literature concerning the characteristics and management of this tumor, which was recently considered to be a different histopathological entity. PMID: 28495088 [PubMed - as supplied by publisher]
Source: Neurocirugia - Category: Neurosurgery Authors: Tags: Neurocirugia (Astur) Source Type: research
We report a case of a sporadic Left optic pathway (nerve/chiasm) glioma treated upfront with Bevacizumab and Vinblastine resulting in significant and sustained recovery of vision. Our patient presented to us with a rapidly increasing lesion arising from the left intracranial optic nerve / chiasm with significant mass effect and peripheral contrast enhancement on serial follow up imaging (MRI). Ophthalmological exam revealed VA of 6/150 (was 6/12) and a 2+ afferent pupillary defect in the left eye. Biopsy of the lesion revealed Pilocytic astrocytoma (WHO Grade-I) which was negative for BRAF (V600E mutation and fusion defect...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: CLINICAL TRIALS AND OUTCOMES - PEDIATRICS Source Type: research
Purpose Vinblastine monotherapy has shown promising activity and a low-toxicity profile in patients with pediatric low-grade glioma (PLGG) who experienced treatment failure after initial treatment with chemotherapy and/or radiation. The aim of this study was to assess the activity of vinblastine in therapy-naïve children. Patients and Methods Patients
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Brain Tumors, Chemotherapy, CNS Tumors Pediatric Oncology Source Type: research
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