Time heals all wounds? A 2-year longitudinal diffusion tensor imaging study in major depressive disorder

Conclusion: This study reports follow-up diffusion tensor imaging data in patients with major depressive disorder after an acute depressive episode. We demonstrated impaired prefrontal white matter microstructure (higher mean diffusivity) at baseline in patients with major depressive disorder, which normalized at follow-up after 2 years, irrespective of disease course. This might have been due to a general treatment effect and might have reflected recovery of white matter integrity. PMID: 31094489 [PubMed - as supplied by publisher]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

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AbstractComics has always had a critical engagement with socio-political and cultural issues and hence evolved into a medium with a subversive power to challenge the status quo. Staying true to the criticality of the medium, graphic medicine (where comics intersects with the discourse of healthcare) critiques the exploitative and unethical practices in the field of healthcare, thereby creating a critical consciousness in the reader. In close reading select graphic pathographies such as Gabby Schulz'sSick (2016), Emily Steinberg'sBroken Eggs (2014), Ellen Forney'sMarbles: Mania, Depression, Michelangelo&Me (2012) and Ma...
Source: Journal of Medical Humanities - Category: Medical Ethics Source Type: research
Conclusions: Our findings may implicate a role of areas associated with self-referential processing in voluntary emotional regulation and lower emotional awareness in patients with functional movement disorders. However, our findings must be replicated with larger sample.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: TLA is associated with an increased risk of depression in men over more than two decades of follow up. Occupational and individual characteristics prior to amputation did not greatly change depression risk following amputation. We speculate that a coordinated combination of social support and medical management may help reduce persistent depression risk in men who experience amputation. PMID: 31405332 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Scand J Public Health Source Type: research
AbstractIntroductionSurgery by open radical hysterectomy for cervical cancer is associated with sexual dysfunction as well as lymphedema and bladder problems. Our aim was to assess the impact of robot ‐assisted laparoscopic radical hysterectomy (RRH) with pelvic lymphadenectomy for early‐stage cervical cancer on sexual, bowel, bladder, and lymphatic function and to measure ovarian function after RRH.Material and methodsTwenty ‐six women with early‐stage cervical cancer during 2011‐2013 were investigated before and 1 year after RRH using a validated questionnaire measuring psychological well‐being and sexua...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
CONCLUSIONS: These finding suggest, for the first time, that neural features across circuits involved in epilepsy may distinguish patients who have depressive symptoms from those who do not. Larger studies are required to validate these findings and to assess their diagnostic utility in MDD. PMID: 31394989 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
In this study we addressed this issue, testing the hypothesis that limbic changes in tinnitus relate to both disease-related distress as well as co-morbid psychopathology. We obtained high-resolution structural magnetic resonance imaging (MRI) scans from a total of 125 subjects: 59 patients with bilateral chronic tinnitus (29 with a co-morbid psychiatric condition, 30 without), 40 healthy controls and 26 psychiatric controls with depression/anxiety disorders (without tinnitus). Voxel-based morphometry with the CAT12 software package was used to analyse data. First, we analysed data based on a 2 × 2 factorial desi...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Abstract Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep disturbances, and depression, as well as reduced fertility and increased long-term risk of cardiovascular disease. POI occurs in ∼1-2% of women, although the etiology of the majority of cases remains unexplained. Approximately 10-20% of POI cases are due to mutations in a single gene or a chromosomal abnormality, which has provided considerable molecular insight into the biological underpinnings of POI. Many of the genes for...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
Authors: Hajnal L, Lazary J Abstract There is a growing body of data on encephalopathy-related psychiatric syndromes in the literature, however, clinical management of them still remains a great challenge. Although organic background of the rarely identified Cotard-syndrome has been reported in numerous pathological states, Hashimoto-encephalopathy has not been published in association with this clinical phenotype so far. In this paper we present a case of a 44 year old woman, who previously never had a psychiatric disorder and her clinical symptoms corresponded to Cotard II syndrome. She produced psychotic depress...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
CONCLUSION: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries. PMID: 31389498 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Psiquiatria - Category: Psychiatry Authors: Tags: Braz J Psychiatry Source Type: research
Conclusion: 11C-AS2471907 has a high fraction of specific binding in vivo in humans and reasonable within-day reproducibility of binding parameters.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
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