Neuronal Intranuclear Inclusion Disease: A Rare Etiology for Rapidly Progressive Dementia.

CONCLUSIONS: NIID is a rare neurodegenerative disorder usually diagnosed postmortem. The rectal and skin biopsy had proved helpful in antemortem diagnosis. We have increased the diagnostic armamentarium by showing the presence of intranuclear inclusions in smooth muscle cells of the muscle. Hence, a high degree of suspicion, magnetic resonance imaging features, with nerve/muscle/skin biopsy can help in diagnosis of NIID. PMID: 31094708 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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DISCUSSION: Dementia subtype is an important predictor of health care costs. Earlier identification and targeted treatment might mitigate the costs associated with co-occurring conditions in LBD. PMID: 31175026 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
DiscussionDementia subtype is an important predictor of health care costs. Earlier identification and targeted treatment might mitigate the costs associated with co-occurring conditions in LBD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Conclusions: The use of antidepressants, especially SNRIs, was associated with a shorter survival time of sCJD patients. The possible changes in neurotransmitters should be emphasized. Scientifically, this study may provide insights into the mechanism of CJD. Clinically, it may contribute to the early diagnosis of CJD.IntroductionDepression is common in the elderly. Its prevalence rate is as high as 11.19%, and this increases progressively with worsening cognitive impairment (1). The presence of depression is an acknowledged risk factor for dementia (2); it can even double the risk for Alzheimer’s disease (AD) (3, 4)...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions Dysautonomic symptoms frequently occuring in α-synucleinopathies comprise cardiovascular, gastrointestinal, urogenital and thermoregulatory disturbances. These symptoms reduce quality of life and worsen prognosis. The understanding of their pathophysiology, as well as the detection of α-synuclein deposition and autonomic dysfunction in the premotor stages of α-synucleinopathies may be key for identifying novel treatment targets and improving clinical outcomes. While causative treatment is not yet available, improvement of quality of life can be achieved by personalized symptomatic treatment r...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
We described palliative care as “aggressive symptom management for maximum quality of life at the present time.”The goal is to treat and remove, or reduce, symptoms that are bothering the person who is deeply forgetful. Symptoms such as pain, or problems like urinary tract infections, are handled in ways that make sense to the person living inAlzheimer ’s World.Learn More -Alzheimer ’s WorldIn the beginning of the journey, when the person is only a little forgetful, diseases and health problems are managed so that the body and mind continue to support each otherFOR MAXIMUM QUALITY OF LIFE IN THE NOW...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimers care alzheimers caregiving dementia help for caregivers end of life care family caregiving help alzheimer's help with dementia care memory care facility nursing home palliative care Source Type: blogs
DiscussionSYGRAVA is the first randomized trial to determine whether programmable ASDs reduce complications of drainage compared to fixed ASDs in patients with iNPH. The results of this study may contribute to health-technology assessment of different valve systems used for VP-shunt surgery, and determination of the future standard of care.Trial registrationInternational Standard Randomised Controlled Trial Number:ISRCTN13838310. Registered on 10 November 2016.
Source: Trials - Category: Research Source Type: clinical trials
I finally learned how to convince a person living with dementia to do what you want them to do.By Bob DeMarcoAlzheimer's Reading RoomAfter readingCommunicating in Alzheimer's World -- our reader Judy commented:So this may work well with the eating, but how about with the going home or someone is stealing from them or trying to hurt them?As anAlzheimer's caregiver it is helpfulto understand that many of the problems you see and are experiencing each day are also being experienced by other Alzheimer's caregivers. There are a lot of common problems.Not wanting to take ashower.Urinary incontinence. Getting up in themiddle of n...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's alzheimer's caregiver resources Alzheimer's family alzheimer's story alzheimers care Alzheimers Dementia care of dementia patients help alzheimer's help with dementia care Source Type: blogs
In order to care effectively for a person living with dementia you must accept the way things are; and then, introduce change into your life.By Bob DeMarcoAlzheimer's Reading RoomDementia patients find it difficult, sometimes impossible, to make decisions. When they say NO they are trying to tell you they can't decide.The word "NO" is one of the most frequently used word in the Alzheimer's World dictionary.What is the Difference Between Alzheimer ’s and Dementia Alzheimer's Communication Tip, No More Blah Blah BlahAs I began to write here in the Alzheimer's Reading Room in 2009,I was forced to think ab...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care Alzheimer's Dementia dementia care dementia help for caregivers help alzheimer's help with dementia care memory care Source Type: blogs
Abstract Nighttime agitation, sleep disturbances, and urinary incontinence (UI) occur frequently in individuals with dementia and can add additional burden to family caregivers, although the co-occurrence of these symptoms is not well understood. The purpose of the current study was to determine the feasibility and acceptability of using passive body sensors in community-dwelling individuals with Alzheimer's disease (AD) by family caregivers and the correlates among these distressing symptoms. A single-group, descriptive design with convenience sampling of participants with AD and their family caregivers was under...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
People living with Alzheimer's and dementia are well known for their challenging and often difficult behaviors.By Bob DeMarcoAlzheimer's Reading RoomWhat can you do about it?Dementia Care, Do You Need to Change?Listen Now or Continue Reading BelowHow to Change Patterns of Behavior in Alzheimer's and Dementia PatientsThe following articles broaden the scope of the podcast; and, should help you to deal with the difficult behaviors you are dealing with each day.1. 7 Ways To Deal With Difficult Behavior Caused By Alzheimer's and DementiaPersons living with Alzheimer's or a related dementia are well known for their ch...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: Alzheimer's family alzheimers and dementia alzheimers education and training alzheimers podcast care of dementia patients dementia care at home help alzheimer's help with dementia care Source Type: blogs
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