World ’s first living organism with fully redesigned DNA created

Researchers create altered synthetic genome, in move with potential medical benefitsScientists have created the world ’s first living organism that has a fully synthetic and radically altered DNA code.The lab-made microbe, a strain of bacteria that is normally found in soil and the human gut, is similar to its natural cousins but survives on a smaller set of genetic instructions.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Science Synthetic biology E coli UK news Health University of Cambridge Source Type: news

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This article reports the characterization and evaluation of the biotechnological potential of a cysteine protease purified from Calotropis procera (CpCP3). This enzyme was highly stable to different metal ions and was able to hydrolyze κ-casein similarly to bovine chymosin. Atomic force microscopy showed that the process of casein micelle aggregation induced by CpCP3 was similar to that caused by chymosin. The cheeses made using CpCP3 showed higher moisture content than those made with chymosin, but protein, fat, and ash were similar. The sensory analysis showed that cheeses made with CpCP3 had high acceptance index ...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 13 October 2019Source: Redox BiologyAuthor(s): Kaibo Xie, Marharyta Varatnitskaya, Abdelouahid Maghnouj, Verian Bader, Konstanze F. Winklhofer, Stephan Hahn, Lars I. LeichertAbstractNeutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling, e.g. during the initiation of the production of neutrophil extracellular traps (NETs). Using...
Source: Redox Biology - Category: Biology Source Type: research
In this study, partially substituted analog D-Arg-W3R6 and completely substituted D-enantiomer D-W3R6 were synthesized. The resistance of D-Arg-W3R6 and D-W3R6 to cleavage by the tested protease increased, particularly of D-W3R6. The antimicrobial activity of D-Arg-W3R6 was almost the same as that of the parent peptide W3R6, but the antimicrobial activity of D-W3R6 was slightly decreased. The hemolytic activity of both D-Arg-W3R6 and D-W3R6 was negligible. The CD spectrum of D-W3R6 exhibited symmetry with that of W3R6 in a membrane-mimetic environment. The membrane interaction between the D-amino acid substituted analogs a...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b05404
Source: Journal of Agricultural and Food Chemistry - Category: Food Science Authors: Source Type: research
Publication date: Available online 12 October 2019Source: Journal of Hospital InfectionAuthor(s): Jaspreet Dhanda, James Gray, Ellen Knox, Amreen Bashir
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionIn summary, our results show that farms are an important reservoir of colistin-resistant E.coli, added to other additional genes, such as blaESBL. The transfer of manure from animals to soil and irrigation water might be spreading a mix of multiple resistances, posing a worrying threat to human health.Graphical abstract
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
AbstractVarious transient metal and metal oxide nanoparticles (NPs) have shown pronounced biological activity, including antibacterial action against different Gram-negative and Gram-positive bacteria including pathogens and drug-resistant ones. Thus, NPs can be applied in nanotechnology for controlling bacterial growth as well as in biomedicine for the treatment of various diseases. However, the mechanisms of these effects are not clear yet. This review is focused on the antibacterial effects of transient metal NPs, especially iron oxide (Fe3O4) and Ag NPs onEscherichia coli wild type and antibiotic-resistant strains. Ag ...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
This study examined the bacteria-reducing properties of copper and stainless-steel metal plates with an added electrical current and up to three filter layers on the growth of Escherichia coli (bacteria) and MS2 bacteriophages (virus). When used with a stainless-steel plate, electricity increased bacteria reduction by 39.5 ± 2.30% in comparison with no electricity added, whereas a three-layer physical barrier decreased its efficiency. Copper also reduced the growth of bacteria, by 58.2 ± 8.23%, and the addition of electricity reduced it further (79.5 ± 2.34%). Bacteriophages were also affec...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
an Syah Microbial infections remains a serious challenge in food industries due to their resistance to some of the well-known antibacterial and antifungal agents. In this work, a novel monomyristoyl ester (fructosyl monomyristate) and two other derivatives (i.e., glucosyl and galactosyl monomyristates) were successfully synthesized from myristic acid and monosaccharides in two-step reactions. First, the myristic acid was converted to myristoyl chloride, and then the myristoyl chloride was reacted with fructose, glucose and galactose separately to produce the corresponding monosaccharide monomyristate derivatives. Th...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 12 October 2019Source: Enzyme and Microbial TechnologyAuthor(s): Soo-Yeon Yang, Tae-Rim Choi, Hye-Rim Jung, Ye-Lim Park, Yeong-Hoon Han, Hun-Suk Song, Ranjit Gurav, Shashi Kant Bhatia, Kyungmoon Park, Jung-Oh Ahn, Yung-Hun YangAbstractGlutaric acid is a C5 dicarboxylic acid that can be used as a building block for bioplastics. Although high concentrations of glutaric acid can be produced by fermentation or bioconversion, a large amount of α-ketoglutaric acid (α-KG) is necessary to accept the amine group from 5-aminovaleric acid. To decrease the demand for α-KG, we introd...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
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