DNA methylation and histone post-translational modifications in the mouse germline following in vitro maturation of fresh or frozen/thawed prepubertal testicular tissue

ConclusionsDespite differences with the in vivo situation, DNA methylation and histone methylation and acetylation occur in the mouse germline in in vitro matured fresh or frozen/thawed mouse prepubertal testicular tissue, and the expression of the enzymes catalyzing these epigenetic modifications are maintained in vitro.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research